Patents

  1. Process for Preparing Amino Acids and Esters, Arthur A. Patchett and William J. Greenlee, U.S. Patent No. 4,275,220 (June 23, 1981).
  2. Process for Preparing Amino Acids and Esters, Arthur A. Patchett and William J. Greenlee, U.S. Patent No. 4,347,375 (August 31, 1982).
  3. Substituted Phosphonamides as Antihypertensives, William J. Greenlee, Elbert E. Harris, Arthur A. Patchett, and Eugene D. Thorsett, U. S. Patent 4,379,146 (April 5, 1983).
  4. Antihypertensive Proline Derivatives, William J. Greenlee, David G. Hangauer, Jr., and Arthur A. Patchett, U. S. Patent No. 4,402,969 (September 6, 1984).
    Process for Preparing Carboxyalkyl Dipeptides, William J. Greenlee, U. S. Patent No. 4,442,030 (April 10, 1984).
  5. 3-Hydroxy-3-(1-Aminoethyl)-2-Azetidinones, William J. Greenlee, Arthur A. Patchett, U. S. Patent No. 4,576,748 (March 18, 1986).
  6. Aza Analogs of Aminoacid Derivatives as Antihypertensives, William J. Greenlee and Eugene D. Thorsett, U. S. Patent No. 4,634,715 (January 6, 1987)
  7. Process for Preparing ACHPA, Paul F. Schuda, William J. Greenlee, Prasun K. Chakravarty and Philip Eskola, U. S. Patent No. 4,788,322 (November 29, 1988).
  8. Renin Inhibitors Containing Phenylalanyl-Histidine Replacements, Arthur A. Patchett, William J. Greenlee, William H. Parsons and Prasun K. Chakravarty, U. S. Patent No. 4,839,357 (June 13, 1989).
  9. Carboxylalkyl Urea Compounds and Derivatives Thereof Useful as Angiotensin Converting Enzyme Inhibitors and as Antihypertensives, William J. Greenlee, David G. Hangauer and Arthur A. Patchett, U. S. Patent No. 4,866,087 (September 12, 1989).
  10. Di- or Tripeptide Renin Inibitors Containing Lactam Conformational Restriction in ACHPA, William J. Greenlee, Daniel F. Veber and Peter D. Williams, U. S. Patent No. 5,006,511 (April 9, 1991).
  11. Renin Inhibitors Containing Phenylalanine-Histidine Replacements, Arthur A. Patchett, William J. Greenlee, William H. Parsons and Parsun K. Chakravarty, U. S. Patent No. 5,037,807 (August 6, 1991).
  12. Renin Inhibitors Containing Phenylalanyl-Histidine Replacements, Arthur A. Patchett, William J. Greenlee and Prasun K. Chakravarty, U. S. Patent No., 5,039,664 (August 13, 1991).
  13. Renin-Inhibitory Di-, Tri- and Tetrapeptides, Jan ten Broeke and William J. Greenlee, U. S. Patent No. 5,049548 (September 17, 1991).
  14. Imidazole Angiotensin II Antagonists Incorporating Acidic Functional Groups, Prasun K. Chakravarty, William J. Greenlee, Elizabeth M. Naylor, Arthur A. Patchett and Thomas F. Walsh, U. S. Patent No. 5,126,342 (June 30, 1992).
  15. Substituted Pyrollo-Fused 6-Membered Heterocycles as Angiotensin II Antagonists, Arthur A. Patchett, Nathan B. Mantlo and William J. Greenlee, U. S. Patent No. 5,124, 335 (June 23, 1992).
  16. HIV Reverse Transcriptase, William J. Greenlee and P. C. Srinivasan, U. S. Patent No. 5,124,327 (June 23, 1992).
  17. Substituted Pyrimidinones as Angiotensin II Antagonists, Eric E. Allen, William J. Greenlee, Prasun K. Chakravarty, Arthur A. Patchett and Thomas F. Walsh, U. S. Patent No. 5,100,897 (March 31, 1992).
  18. Substituted Imidazo-Fused 6-Membered Heterocycles as Angiotensin II Antagonists, Prasun K. Chakravarty, William J. Greenlee, Nathan B. Mantlo, Arthur A. Patchett and Thomas F. Walsh, U. S. Patent No. 5,102,880 (April 7, 1992).
  19. Angiotensin II Antagonists Incorporating an Indole or Dihydroindole, Scott Bagley, William J. Greenlee, Daljit S. Dhanoa and Arthur A. Patchett, U. S. Patent No. 5,151,435 (September 29, 1992).
  20. Oxo-Purines as Angiotensin II Antagonists, Prasun K. Chakravarty, William J. Greenlee, Nathan B. Mantlo, Arthur A. Patchett and Thomas F. Walsh, U. S. Patent No. 5,157,026 (October 20, 1992).
  21. Substituted Quinolines as Angiotensin II Antagonists, William J. Greenlee, David B. R. Johnston and Malcolm MacCoss, U. S. Patent No. 5,157,040 (October 20, 1992).
  22. Substituted 1-(2H)-Isoquinolinones Bearing Acidic Functional Groups as Angiotensin II Antagonists, Prasun K. Chakravarty, William J. Greenlee, Nathan B. Mantlo, Arthur A. Patchett and Dooseop Kim, U. S. Patent No. 5,162,340 (November 10, 1992).
  23. Substituted Imidazo-Fused 5-Membered Ring Heterocycles and Their Use as Angiotensin II Antagonists, William J. Greenlee, David B. R. Johnston, Malcolm MacCoss, Nathan B. Mantlo, Arthur A. Patchett, Prasun K. Chakravarty and Thomas F. Walsh, U. S. Patent No. 5,164,407 (November 17, 1992).
  24. Substituted Pyrimidines, Pyrimidinones and Pyridopyrimidines, Eric E. Allen, William J. Greenlee, Malcolm MacCoss and Arthur A. Patchett, U. S. Patent No. 5,166,206 (November 24, 1992).
  25. Angiotensin II Antagonists Incorporating a Substituted Indole or Dihydroindole, Scott Bagley, William J. Greenlee, Daljit S. Dhanoa and Arthur A. Patchett, U. S. Patent No. 5,175,164 (December 29, 1992).
  26. Triazole Angiotensin II Antagonists Incorporating a Substituted Benzyl Element, William J. Greenlee, Arthur A. Patchett, David Hangauer, Wallace Ashton, Kenneth J. Fitch, Thomas F. Walsh, Ralph A. Rivero and Daljit S. Dhanoa, U. S. Patent No. 5,177,095 (January 5, 1993).
  27. Imidazole Angiotensin II Antagonists Incorporating a Substituted Benzyl Element, William J. Greenlee, Arthur A. Patchett, David Hangauer, Thomas F. Walsh, Kenneth J. Fitch, Ralph A. Rivero and Daljit S. Dhanoa, U. S. Patent No. 5,183,810 (February 2, 1993).
  28. Angiotensin II Antagonists Incorporating a Substituted 1,3-Benzodioxole or 1,3-Benzodithiole, William J. Greenlee and Ralph A. Rivero, U. S. Patent No. 5,187,159 (February 16, 1993).
  29. Cyclic Renin Inhibitors Containing 2-Substituted (3S, 4S)-4-Amino-5-Cyclohexyl-3-Hydroxy Pentanoic Acid, 2-Substituted (3S,4S)-5-Cyclohexyl-3,4-Dihydroxypentanoic Acid or 2-Substituted (4S,5S)-5-Amino-6-Cyclohexyl-4-Hydroxyhexanoic Acid or its Analogs, William J. Greenlee, Ralph A. Rivero Ann E. Weber, Lihu Yang, U. S. Patent No. 5,194,605 (March 16, 1993).
  30. Imidazole Derivatives Bearing Acidic Functional Groups at the 5-Position, Their Compositions and Methods of Use as Angiotensin II Antagonists, Prasun K. Chakravarty, William J. Greenlee, Arthur A. Patchett, U. S. Patent No. 5,236,928 (August 17, 1993).
  31. Substituted Pyrazolopyrimidines as Angiotensin II Antagonists, Eric E. Allen, William J. Greenlee, Prasun K. Chakravarty, Malcolm MacCoss, Arthur A. Patchett and Thomas F. Walsh, U. S. Patent No. 5,2520,521 (October 5, 1993).
  32. Cyclic Renin Inhibitors Containing 3(S)-Amino-4-Cyclohexyl-2(R)-Hydroxy-Butanoic Acid or 4-Cyclohexyl-(2R, 3S)-Dihydroxybutanoic Acid or Related Analogs, Daljit S. Dhanoa, Arthur A. Patchett, William J. Greenlee, William H. Parsons, Thomas A. Halgren, Ann E. Weber and Lihu Yang, U. S. Patent No. 5,254,682 (October 19, 1993).
  33. Substituted Imidazopyridines as Angiotensin II Antagonists, Eric. E. Allen, William J. Greenlee, Prasun K. Chakravarty, Malcolm MacCoss, Arthur A. Patchett and Thomas F. Walsh, U. S. Patent No. 5,260,285 (November 9, 1993).
  34. (Biphenylmethyl)pyrazole Angiotensin II Antagonists, Wallace T. Ashton, Linda L. Chang, William J. Greenlee and Steven M. Hutchins, U. S. Patent No. 5,262,412 (December 3, 1993).
  35. Substituted 1,2,4-Triazoles Bearing Acidic Functional Groups as Angiotensin II Antagonists, Wallace T. Ashton, Prasun K. Chakravarty, Linda L. Chang, William J. Greenlee, Dooseop Kim, Nathan B. Mantlo and Arthur A. Patchett, U. S. Patent No. 5,281614 (January 25, 1994).
  36. N,N-Diacylpiperazines, Wallace T. Ashton, Conrad P. Dorn, William J. Greenlee, Malcolm MacCoss, Sander G. Mills and Mu-Tsu Wu, U. S. Patent No. 5,292,726 (March 8, 1994).
  37. Substituted Carbamoyl and Oxycarbonyl Derivatives of Biphenylmethylamides, Wallace T. Ashton, Linda L. Chang, William J. Greenlee, Steven M. Hutchins and Ralph A. Rivero, U. S. Patent No. 5,312,820 (May 17, 1994).
  38. Substituted Imidazo-Fused 6-Membered Heterocycles as Angiotensin II Antagonists, Prasun K. Chakravarty, William J. Greenlee, Nathan B. Mantlo, Arthur A. Patchett and Thomas F. Walsh, U. S. Patent No. 5,332,744 (June 26, 1994).
  39. Substituted Pyrimidines, Pyrimidinones and Pyridopyrimidines, Eric E. Allen, William J. Greenlee, Malcolm MacCoss and Arthur A. Patchett, U. S. Patent No. 5,324,729 (June 28, 1994).
  40. Six-Membered Ring Fused Imidazoles Substituted with Phenoxyphenylacetic Acid Derivatives, Prasun K. Chakravarty, Kenneth J. Fitch, Elizabeth M. Naylor, James R. Tata, Thomas F. Walsh, David L. Williams and William J. Greenlee, U. S. Patent No. 5,334,598 (August 2, 1994).
  41. N,N-Diacylpiperazine Tachykinin Antagonists, Sander G. Mills, Richard J. Budhu, Conard P. Dorn, William J. Greenlee, Malcolm MacCoss and Mu Tsu Wu, U. S. Patent No. 5,344,830 (September 6, 1994).
  42. N,N’-Diacylpiperazines as Angiotensin II Antagonists, William J. Greenlee and Mu-Tsu Wu, U. S. Patent No. 5,348,955 (September 20, 1994).
  43. Disubstituted 6-Aminoquinazolinones, Stephen E. de Laszlo, Thomasz W. Glinka, William J. Greenlee, Prasun K. Chakravarty and Arthur A. Patchett, U. S. Patent No. 5,385,894 (January 31, 1995).
  44. Substituted Imidazo-fused 5-Membered Ring Heterocycles as Angiotensin II Antagonists, William J. Greenlee, David B. R. Johnston, Malcolm MacCoss, Nathan B. Mantlo, Arthur A. Patchett, Prasun K. Chakravarty and Thomas F. Walsh, U. S. Patent No. 5,389,660 (February 14, 1995).
  45. Substituted Triazolinones, Triazolinethiones, and Triazolinimines as Angiotensin II Antagonists, Wallace T. Ashton, Linda L. Chang, Malcolm MacCoss, Prasun K. Chakravarty, William J. Greenlee, Arthur A. Patchett and Kelly Flanagan, U. S. Patent No. 5,411,980 (May 2, 1995).
  46. Heterocyclic Compounds Bearing Acidic Functional Groups as Angiotensin II Antagonists, Prasun K. Chakravarty, William J. Greenlee, Dooseop Kim, Nathan B. Mantlo, Arthur A. Patchett and Ralph A. Rivero, U. S. Patent No. 5,412,097 (May 2, 1995).
  47. Substituted Quinazolinones Bearing Acidic Functional Groups as Angiotensin II Antagonists, Prasun K. Chakravarty, Stephen de Laszlo, Thomas W. Glinka, William J. Greenlee, Nathan B. Mantlo and Arthur A. Patchett, U. S. Patent No. 5,441,959 (August 15, 1995).
  48. Angiotensin II Antagonists Incorporating a Substituted Benzyl Element, William J. Greenlee, David Hangauer, Arthur A. Patchett, Thomas F. Walsh, Kenneth J. Fitch, Daljit S. Dhanoa and Ralph A. Rivero, U. S. Patent No. 5,449,682 (September 12, 1995).
  49. Endothelin Antagonists Bearing 5-Membered Heterocyclic Amides, Wallace T. Ashton, Linda L. Chage and William J. Greenlee, U. S. Patent No. 5,538,991 (July 23, 1996).
  50. Substituted Biphenylmethylimidazopyridines, Ralph A. Rivero, Prasun K. Chakravarty, William J. Greenlee, Nancy J. Kevin and Nathan B. Mantlo, U. S. Patent No. 5,554,625 (September 10, 1996).
  51. Endothelin Antagonists Bearing Pyridyl Amides, Wallace T. Ashton, Linda L. Chang and William J. Greenlee, U. S. Patent No. 5,559,135 (September 24, 1996).
  52. Biphenyl Compounds Useful As Endothelin Antagonists, Scott W. Bagley, Theodore P. Broten, Prasun K. Chackravarty, Daljit S. Dhanao, Kenneth J. Fitch, William J. Greenlee, Nancy Jo Kevin, Douglas J. Pettibone, Ralph A. Rivero, Thomas F. Walsh, David L. Williams, Jr., Richard B. Toupence and Jay M. Matthews, U. S. Patent No. 5,565,485 (October 15, 1996).
  53. Endothelin Antagonists, William J. Greenlee and Thomas F. Walsh, U. S. Patent No. 5,686,478 (November 11, 1997).
  54. Phenoxyphenylacetic Acid Derivatives, Scott W. Bagley, Theodore P. Broten, Prasun K. Chackravarty, Daljit S. Dhanao, Kenneth J. Fitch, William J. Greenlee, Nancy Jo Kevin, Gerard R. Kieczykowski, Douglas J. Pettibone, James R. Tata, Ralph A. Rivero, Thomas F. Walsh, David L. Williams, Jr., Jay M. Matthews and Richard B. Toupence, U. S. Patent No. 5,668,176 (September 16, 1997).
  55. Phenoxyphenylacetic Acid Derivatives, Scott W. Bagley, Theodore P. Broten, Prasun K. Chackravarty, Daljit S. Dhanao, Kenneth J. Fitch, William J. Greenlee, Nancy Jo Kevin, Douglas J. Pettibone, Ralph A. Rivero, James R. Tata, Thomas F. Walsh and David L. Williams, Jr., U. S. Patent No. 5,767,310 (June 16, 1998).
  56. Certain 1-(2-Naphthyl) and 1-(2-azanaphthyl)-4-(1-phenylmethyl)piperazines, Dopamine Receptor Subtype Selective Ligands, William J. Greenlee, Ashit K. Ganguly and Jan W. F. Wasley, U. S. Patent No. 6,040,448 (March 21, 2000).
  57. Certain 1-(2-Naphthyl) and 1-(2-azanaphthyl)-4-(1-phenylmethyl)piperazines, Dopamine eptor Subtype Selective Ligands, William J. Greenlee, Ashit K. Ganguly and Jan W. F. Wasley, . Patent No. 6,384,224 (May 7, 2002).
  58. Muscarinic Antagonists, Craig D. Boyle, William J. Greenlee and Samuel Chackalamannil, U.S. Patent No. 6,890,936 (May 10, 2005).
  59. Adenosine A2A Receptor Antagonists, Craig D. Boyle, Samuel Chackalamannil, William J. Greenlee, Unmesh Shah and Yan Xia, U.S. Patent No. 6,916811 (July 12, 2005).
  60. Adenosine A2A Receptor Antagonists, Bernard R. Neustadt, Neil Lindo, William J. Greenlee, Deen Tulshian, Lisa S. Silverman, Yan Xia, Craig D. Boyle and Samuel Chackalamannil, U. S. Patent No. 6,897,216 (May 24, 2005).
  61. Adenosine A2A Receptor Antagonists, Craig D. Boyle, Samuel Chackalamannil, William J. Greenlee, Unmesh G. Shah and Yan Xia, U. S. Patent No. 6,916,811 (July 12, 2005).
  62. Selective D1/D5 Receptor Antagonists for the Treatment of Obesity and CND Disorders, Wen-Lian Wu, Duane Burnett, William J. Greenlee and Thavalakulamgara K. Sasikumar, U. S. Patent No. 7,211,574 (May 1, 2007).
  63. Thrombin Receptor Antagonists, Samuel Chackalamannil, William J. Greenlee, Yuguang Wang, Wenxue Wu, Enrico P. Veltri and Yan Xia, U.S. Patent No. 7,304,078 (December 4, 2007).
  64. Neuropeptide Receptor Modulators, Zhaoning Zhu, Zhong-Yue Sun, Yuanzan C. Ye, bora E. Mullins, Brian McKittrick, Andrew Stamford, William J. Greenlee, U. S. Patent No. 9,450 B2 (December 2, 2008)
  65. 2-Substituted Benzimidazole Piperidines Analogs as Selective Melanin Concentrating mone Receptor Antagonists For the Treatment of Obesity and Related Disorders, Duane A. nett, Wen-Lian Wu, T. K. Sasikumar and William J. Greenlee, U. S. Patent No. 7, 511,146 rch 31, 2009).
  66. Heterocyclic Aspartyl Protease Inhibitors, Zhaoning Zhu, Brian McKittrick, Zhong-Yue Sun, nzan C. Ye, Johannes Voigt, Corey Strickland, Elizabeth M. Smith, Andrew Stamford, William reenlee, Robert Mazzola, John Caldwell, Jared N. Cumming, Lingyan Wang, Yusheng Wu, ch Iserloh, Tao Guo, Thuy X. H. Le, Kurt W. Saionz, Suresh D. Babu, Rachel Hunter, U. S. nt No. 7,592,348 B2 (September 22, 2009).
  67. Pyridothienopyridazinone Derivatives as mGluR1 Antagonists, Chad E. Bennett, William S. Greenlee, Chad E. Knutson, Duane A. Burnett, US Patent No. 7,687,501 (March 30, 2010).
  68. Heterocyclic Aspartyl Protease Inhibitors, Zhaoning Zhu, Brian A. McKittrick, Zhong-Yue Sun, Yuanzan C. Ye, Johannes H. Voigt, Corey Strickland, Elizabeth M. Smith, Andrew Stamford, Willam J. Greenlee, Robert Mazzola, John Caldwell, Jared N. Cumming, Lingyan Wang, Yusheng Wu, Ulrich Iserloh, Tao Guo, Thuy X. H. Le, Kurt W. Saionz, Suresh D. Babu, Rachael C. Hunter, Michelle L. Morris, Gang Qian, and Dawit Tadesse, US Patent No. 7,700,603 B2 (April 20, 2010).
  69. Substituted Piperazines as CB1 Antagonists, Eric J. Gilbert, Michael W. Miller, Jack D. Scott, Andrew W. Stamford, William J. Greenlee and Jay Weinstein, US Patent No. 7,700,597 B2 (April 20, 2010).
  70. Thrombin Receptor Antagonists, Samuel Chackalamannil, Martin C. Clasby, William J. Greenlee, Yuguang Wang, Yan Xia, Enrico P. Veltri and Mariappan V. Chelliah, US Patent No. 7,713,999 B2 (May 11, 2010).
  71. Heterocyclic Aspartyl Protease Inhibitors, Zhaoning Zhu, Brian McKittrick, Zhong-Yue Sun, Yuanzan C. Ye, Johannes H. Voigt, Corey O. Strickland, Elizabeth M. Smith, Andrew Stamford, William J. Greenlee, Robert D. Mazzola, John P. Caldwell, Jared N. Cumming, Lingyan Wang, Yusheng Wu, Ulrich Iserloh, Xiaoxiang Liu, Tao Guo, Thu X. E. Le, Kurt W. Saionz, Suresh D. Babu, Rachael C. Hunter, Michelle L. Morris, Huizhong Gu, Gang Qian, Dawit Tadesse, Ying Huang, Guoqing Li, Jianping Pan, Jeffrey A. Misiaszek, Gaifa Lai, Jingqi Duo, Chuangxing Qu and Yuefei Shaom US Patent No. 7,773,609 (July 27, 2010).
  72. Aspartyl Protease Inhibitors, Zhaoning Zhu, Brian McKittrick, Andrew Stamford, William J. Greenlee, Xiaoxiang Liu, Mihirbaran Mandal, Johannes H. Voigt, and Corey O. Strickland, US Patent No. 7,868,000 B2 (January 11, 2011).
  73. Aspartyl Protease Inhibitors, Zhaoning Zhu, Brian McKittrick, Zhong-Yue Sun, Yuanzan C. Ye, Johannes H. Voigt, Corey O. Strickland, Elizabeth M. Smith, Andrew Stamford, William J. Greenlee, Robert D. Mazzola, John P. Caldwell, Jared N. Cumming, Lingyan Wang, Yusheng Wu, Ulrich Iserloh, Tao Guo, Thuy Le, Kurt W. Saionz, Suresh D. Babu, Rachel C. Hunter, Michelle L. Morris, Huizhong Gu, Gang Qian, and Dawit Tadesse, US Patent No. 7,973,067 (July 5, 2011).
  74. Aspartyl Protease Inhibitors, Zhaoning Zhu, Brian McKittrick, Zhong-Yue Sun, Yuanzan C. Ye, Johannes H. Voigt, Corey O. Strickland, Elizabeth M. Smith, Andrew Stamford, William J. Greenlee, Robert D. Mazzola, John P. Caldwell, Jared N. Cumming, Lingyan Wang, Yusheng Wu, Ulrich Iserloh, Tao Guo, Thuy Le, Kurt W. Saionz, Suresh D. Babu, Rachel C. Hunter, Michelle L. Morris, Huizhong Gu, Gang Qian, and Dawit Tadesse, US Patent No. 7,973,067 (July 5, 2011).
  75. Heterocyclic Aspartyl Protease Inhibitors, Zhaoning Zhu, Zhong-Yue Sun, Andrew Stamford, William Greenlee, Jared N. Cumming, Lingyan Wang, Ulrich Iserloh, Xiaoxiang Liu, Ying Huang, Guoqing Li, Jianping Pan, US Patent No. 8,183,252 (May 22, 2012).
  76. Heterocyclic aspartyl protease inhibitors, Zhaoning Zhu, Brian McKittrick, Zhong-Yue Sun, Yuanzan C. Ye, Johannes H., Voigt, Corey Strickland, Elizabeth M. Smith, Andrew W. Stamford, William J. Greenlee, Robert D. Mazzola, Jr., John P. Caldwell, Jared N. Cumming, Lingyan Wang, Yusheng Wu, Ulrich Iserloh, Tao Guo, Thuy X. H. Le, Kurt W. Saionz, Suresh D. Babu, Rachael C. Hunter, Michelle L. Morris, Huizhong Gu, Gang Qian, Dawit Tadesse, US Patent No. 8242112 (August 14, 2012).
  77. Gamma secretase modulators, Zhaoning Zhu, William J. Greenlee, Zhong-Yue Sun, Gioconda Gallo, Theodros Asberom, Xianhai Huang, Xiaohong Zhu, Edison, Mark D. McBriar, Dmitri A. Pissarnitski, Zhiqiang Zhao, Ruo Xu, Hongmei Li, Anandan Palani, Johannes H. Voigt, Robert D. Mazzola, Jr., John Clader, Hubert Josien, and Jun Qin, US Patent 8,357,682 B2 (January 22, 2013).
  78. Spiro-imidazolone derivatives as glucagon receptor antagonists, Andrew Stamford, Michael W. Miller, Duane Eugene DeMong, William J. Greenlee, Joseph A. Kozlowski, Brian J. Lavey, Michael K. C. Wong, Wensheng, Xing Dai, De-Yi Yang, Guowei Zhou, US Patent 8,361,959 (January 29, 2013). 
  79. Gamma Secretase Modulators, Zhaoning Zhu,; William J.; Greenlee, Xianhai Huang,; Brian A.; McKittrick, John W.; Clader, Mark D.; McBriar, and AnandanPalani, US Patent 8,426,403 (April 23, 2013).
  80. Gamma Secretase Modulators, Xianhai Huang, Andandan Palani, Jun Qin Jun, Robert G. Aslanian, Zhaoning Zhu, William Greenlee, Hubert Josien, Wei  Zhou, Xiaohong Zhu, Chad E. Bennett, Dmitri Pissarnitski, Mihirbaran Mandal, Pawan Dhondi, Troy McCracken, Thomas Bara, Zhiqiang Zhao, Duane Burnett, John Clader, US Patent 8,450,343 (May 28, 2013).
  81. Thiophenes as glucagon receptor antagonists, compositions, and methods for their use, Eric J. Gilbert, Michael W. Miller, Andrew W. Stamford, William J. Greenlee, US Patent 8,470,773 (June 25, 2013).
  82. Gamma Secretase Modulators, William J. Greenlee, Zhaoning Zhu, Theodros Asberom, Xianhai Huang, Hubert B. Josien, US Patent 8,487,099 (July 16, 2013).
  83. Gamma Secretase Modulators, Robert G. Aslanian, Xianhai Huang, Anandan Palani, Jun Qin, Wei Zhou, Xiaohong Zhu, Robert D. Mazzola, Jr., Pawan Dhondi, and William J. Greenlee, US Patent 8,487,099 (August 27, 2013).
  84. Bicyclic piperidine and piperazine derivatives as GPCR modulators for the treatment of obesity, diabetes and other metabolic disorders, Craig D. Boyle, Claire M. Lankin, Unmesh G. Shah, William J. Greenlee and Samuel Chackalamannil, US Patent 8,580,807 (November 12, 2013).
  85. 4, 5, 6-trisubstituted pyrimidine derivatives as factor IXa inhibitors, Mariappan V., Chelliah; Samuel Chackalamannil, William J. Greenlee, Keith Eagan, Zhuyan Guo, Martin C. Clasby, Yan Xia, Charles L. Jayne, Michael Dwyer, Kartik M. Keertikar, Tin-Yau Chan, Li Wang, US Patent 8,609,676 (December 17, 2013).
  86. Substituted piperazines as CB1 antagonists, Eric J. Gilbert, Michael W. Miller, Jack D. Scott, Duane Eugene DeMong, Andrew Stamford, William J. Greenlee and Chander Shekher Celly, US Patent 8623873 (January 7, 2014).
  87. Glucagon Receptor Antagonists, Compositions, and Methods for Their Use, William J. Greenlee, Andrew Stamford, Michael W. Miller, Duane Eugene DeMong, US Patent 8,623,818 (January 7, 2014).
  88. Substituted isoindolines as aspartyl protease inhibitors, Andrew Stamford, Guoqing Li, William Greenlee, Zhaoning Zhu, Brian McKittrick, Robert Mazzola, Ying Huang, Tao Guo, Thuy X. H. Le, Gang Qian, Yuefei Shao, US Patent 8,722,708 (May 13, 2014).
  89. Factor IXa inhibitors, Craig Boyle, William Greenlee, Samuel Chackalamannil and Claire Lankin, U. S. Patent 9,161924 (October 20, 2015).
  90. Substituted biaryl derivatives and methods of use thereof, Craig D. Boyle, Claire M. Lankin, William J Greenlee and Joel M. Harris, US Patent 9,301,929 (April 5, 2016).
  91. Preparation and use of bicyclic himbacine derivatives as PAR-1 receptor antagonists, Mihir Mandal, Timothy A. Blizzard, Helen Chen, Harry Chobanian, Yan Guo, Barbara Pio, Zhicai Wu, Tesfaye Biftu, William J. Greenlee and Johnny Zhaoning Zhu, US Patent 9,340,530 (May 17, 2016).