Publications

  1. Paul G. Gassman and William J. Greenlee. Chemistry of Bent Bonds XXX. A Simple Approach to Azulenes, Syn. Comm., 2, 395-398 (1972).
  2. Paul G. Gassman and William J. Greenlee. Chemistry of Bent Bonds XXXVI. Photolysis of Substituted Derivatives of 2,3-Diazabicyclo[3.1.0]-hex-2-ene. A Simple Route to Certain Bicyclo[1.1.0]butanes, J. Amer. Chem. Soc., 95, 980-982 (1973).
  3. P. G. Gassman and W. J. Greenlee. Dideuteriodiazomethane, Org. Syn., 53, 38 (1973).
  4. W. J. Greenlee and R. B. Woodward. Total Synthesis of Marasmic Acid, J. Amer. Chem. Soc., 98, 6075 (1976).
  5. W. J. Greenlee, D. Taub and A. A. Patchett. A General Synthesis of α-Vinyl-α-Amino Acids, Tetrahedron Letts., 3999 (1978).
  6. G. Stork, Y. Nakahara, Y. Nakahara and W. J. Greenlee. Total Synthesis of Cytochalasin B, J. Amer. Chem. Soc., 100, 9775 (1978).
  7. A. A. Patchett, E. Harris, E. W. Tristram, M. J. Wyvratt, M. T. Wu, D. Taub, E. R. Peterson, T. J. Ikeler, J. ten Broeke, L. G. Payne, D. L. Ondeyka, E. D. Thorsett, W. J. Greenlee, N. S. Lohr, R. D. Hoffsommer, H. Joshua, W. V. Ruyle, J. W. Rothrock. S. D. Aster, A. L. Maycock, F. M. Robinson and R. Hirschmann. A New Class of Angiotensin-Converting Enzyme Inhibitors, Nature, 288, 280 (1980).
  8. W. J. Greenlee and R. B. Woodward. Marasmic Acid I; Total Synthesis of (+/-)-Isomarasmic Acid, Tetrahedron, 36, 3361 (1980).
  9. W. J. Greenlee and R. B. Woodward. Marasmic Acid II; Total Synthesis of (+/-)-Marasmic Acid. Tetrahedron, 36, 3366 (1980).
  10. W. J. Greenlee and E. D. Thorsett. Mild Conversion of Carboxamides and Carboxylic Acid Hydrazides to Acids and Esters, J. Org. Chem., 46, 5351 (1981).
  11. E. D. Thorsett, E. E. Harris, E. R. Peterson, W. J. Greenlee, A. A. Patchett, E. H. Ulm and T. C. Vassil. Phosphorous-Containing Inhibitors of Angiotensin-Converting Enzyme, Proc. Natl. Acad. Sci. USA, 79, 2176 (1982).
  12. W. J. Greenlee. Preparation of Substituted N-Carboxymethyl Dipeptides, Tetrahedron Letts., 23, 3995 (1982).
  13. W. J. Greenlee and D. G. Hangauer. Addition of Trimethylsilylcyanide to α-Substituted Ketones: Catalyst Efficiency, Tetrahedron Letts., 24, 4559 (1983).
  14. W. J. Greenlee. Synthesis of β,γ-Unsaturated Amino Acids by the Strecker Reaction, J. Org. Chem., 49, 2632 (1984).
  15. W. J. Greenlee, E. D. Thorsett, J. P. Springer and A. A. Patchett. Azapeptide Inhibitors of Angiotensin-Converting Enzyme, Biochem. Biophys. Res. Commun., 122, 791 (1984).
  16. William J. Greenlee, Patricia L. Allibone, Debra S. Perlow, Arthur A. Patchett, Edgar H. Ulm and Theodore C. Vassil. Angiotensin-Converting Enzyme Inhibitors: Synthesis and Biological Activity of Acyltripeptide Analogs of Enalapril, J. Med. Chem., 28, 434 (1985).
  17. N. A. Thornberry, H. G. Bull, D. Taub, W. J. Greenlee, A. A. Patchett and E. H. Cordes. 3-Halovinylglycines. Efficient Irreversible Inhibitors of E. Coli Alanine Racemase, J. Amer. Chem. Soc., 109, 7543 (1987).
  18. W. J. Greenlee. Renin Inhibitors, Pharmaceutical Research, 4, 364 (1987).
  19. P. K. Chakravarty, P. Combs, A. Roth and W. J. Greenlee. An Efficient Synthesis of λ-Amino-β-Ketophosphonates From α-Amino Acids, Tetrahedron Letts., 28, 611 (1987).
  20. Mark G. Bock, Robert M. DiPardo, Ben E. Evans, Kenneth E. Rittle, Joshua Boger, Martin Poe, Bruce I. LaMont, Robert J. Lynch, Edgar H. Ulm, George P. Vlasuk, William J. Greenlee and Daniel F. Veber. Renin Inhibitors. Statine-Containing Tetrapeptides with Varied Hydrophobic Carboxy Termini, J. Med. Chem., 30, 1853 (1987).
  21. P. F. Schuda, W. J. Greenlee, P. K. Chakravarty, and P. Eskola. A short and Efficient Synthesis of (3S,4S)-4-[(tert-Butoxycarbonyl)amino]-5-cyclohexyl-3-hydroxypentanoic Acid Ethyl Ester, J. Org. Chem., 53, 873 (1988).
  22. William J. Greenlee, James P. Springer and Arthur A. Patchett. Synthesis of an Analog of Tabtoxin as a Potential Inhibitor of D-Alanine:D-Alanine Ligase (ADP Forming), J. Med. Chem., 32, 165 (1989).
  23. P. K. Chakravarty, W. J. Greenlee, W. H. Parsons, A. A. Patchett, P. Combs, A. Roth, R. D. Busch and T. N. Mellin. (3-Amino-2-oxoalkyl)phosphonic Acids and Their Analogues as Novel Inhibitors of D-Alanine-D-Alanine Ligase, J. Med. Chem., 32, 1886 (1989).
  24. Richard Saperstein, Pasquale P. Vicario, H. Vincent Strout, Edward Brady, Eve E. Slater, William J. Greenlee, Debra L. Ondeyka, Arthur A. Patchett and David G. Hangauer. Design of a Selective Insulin Receptor Tyrosine Kinase Inhibitor and Its Effects on Glucose Uptake and Metabolism in Intact Cells, Biochemistry, 28, 5694 (1989).
  25. William J. Greenlee. Renin Inhibitors, Med. Res. Rev., 10, 173 (1990).
  26. S. E. deLaszlo, B. L. Bush, J. J. Doyle, W. J. Greenlee, D. G. Hangauer, T. A. Halgren, R. J. Lynch, T. W. Schorn and P. K. S. Siegl. The Synthesis and Use of 3-Amino-4-Phenyl-2-Piperidones and 4-Amino-2-Benzazepinones as Conformationally-Restricted Phenylalanine Isosteres in Renin Inhibitors, in Peptides, Chemistry, Structure and Biology, Proceedings of the Eleventh American Peptide Symposium, J. E. Rivier and G. R. Marshall, eds., Escom Science Publishers, B. V., Leiden, 1990, p. 409.
  27. William J. Greenlee, Jan tenBroeke, Stephen E. deLaszlo, Prasun K. Chakravarty, Valerie J. Camara, Kenneth J. Fitch, Carol S. Sarnella, Arthur A. Patchett, Peter D. Williams, Debra S. Perlow, Daniel F. Veber, Robert J. Lynch, John J. Doyle, Terry W. Shorn, John F. Strouse and Peter K. S. Siegl. Approaches to Human Renin Inhibitors With Improved Bioavailability, in Peptides, Chemistry, Structure and Biology, Proceedings of the Eleventh American Peptide Symposium, J. E. Rivier and G. R. Marshall, eds., Escom Science Publishers, B. V., Leiden, 1990, p. 411.
  28. R. A. Jupp, B. M. Dunn, J. W. Jacobs, G. Vlasuk, K. E. Arcuri, D. F. Veber, D. S. Perlow, L. S. Payne, J. Boger, S. deLaszlo, P. K. Chakravarty, J. tenBroeke, D. G. Hangauer, D. Ondeyka, W. J. Greenlee and J. Kay. The Selectivity of Statine-Based Inibitors Against Various Human Aspartic Proteinases, Biochem. J., 265, 871 (1990).
  29. L. W. Schaffer, T. W. Schorn, R. J. Winquist, J. F. Strouse, L. Payne, P. K. Chakravarty, S. E. deLaszlo, J. tenBroeke, D. F. Veber, W. J. Greenlee and P. K. S. Siegl. Acute Hypotensive Responses to Peptide Inhibitors of Renin in Conscious Monkeys: An Effect on Blood Pressure Independent of Plasma Renin Inhibition, J. Hypertension, 8, 251 (1990).
  30. W. J. Greenlee and A. E. Weber. Renin Inhibitors, Drug News and Perspectives, 4, 332 (1991).
  31. W. J. Greenlee and Peter K. S. Siegl. Angiotensin / Renin Modulators, Annual Reports in Medicinal Chemistry, Vol. 26, Chapter 7, pp 63-72 (1991).
  32. R. A. Rivero and W. J. Greenlee. The Synthesis of Novel Macrocyclic Inhibitors of Human Renin, Tetrahedron Letts., 32, 2453 (1991).
  33. R. A. Rivero, W. J. Greenlee and A. A. Patchett. Sulfones as Peptide Bond Isosteres, Tetrahedron Letts., 32, 5263 (1991).
  34. A. E. Weber, T. A. Halgren, J. J. Doyle, R. J. Lynch, P. K. S. Siegl, W. H. Parsons, W. J. Greenlee and A. A. Patchett. Design and Synthesis of P2-P2’-Linked Macrocyclic Human Renin Inhibitors, J. Med. Chem., 34, 2692 (1991).
  35. N. B. Mantlo, P. K. Chakravarty, D. L. Ondeyka, P. K. S. Siegl, R. S. Chang, V. J. Lotti, K. A. Faust, T.-B. Chen, T. W. Schorn, C. S. Sweet, S. E. Emmert, A. A. Patchett and W. J. Greenlee. Potent, Orally Active Imidazo[4,5-b]pyridine-Based Angiotensin II Antagonists, J. Med. Chem., 34, 2919 (1991).
  36. P. D. Williams, L. S. Payne, D. S. Perlow, M. K. Holloway, P. K. S. Siegl, T. W. Schorn, R. J. Lynch, J. J. Doyle, J. F. Strouse, G. P. Vlasuk, K. Hoogsteen, J. P. Springer, B. L. Bush, T. A. Halgren, J. tenBroeke, W. J. Greenlee, A. D. Richards, J. Kay and D. F. Veber. Design of Renin Inhibitors Containing Conformationally-Restricted Mimetics of the P1-P1’ and P1 Through P2’ Sites, Structure and Function of the Aspartic Proteinases, B. M. Dunn, Ed., Plenum Press, New York, 1991, pp 325-334.
  37. W. T. Ashton, C. L. Cantone, L. C. Meurer, R. L. Tolman, W. J. Greenlee, A. A. Patchett, R. J. Lynch, T. W. Schorn, J. F. Strouse and P. K. S. Siegl. Renin Inhibitors Containing C-Termini Derived from Mercaptoheterocycles, J. Med. Chem., 35, 2103 (1992).
  38. S. E. de Laszlo, B. L. Bush, J. J. Doyle, W. J. Greenlee, D. G. Hangauer, T. A. Halgren, R. J. Lynch, T. W. Schorn and P. K. S. Siegl. Synthesis and Use of 3-Amino-4-phenyl-2-piperidones and 4-Amino-2-benzazepin-3-ones as Conformationally Restricted Phenylalanine Isosteres in Renin Inhibitors, J. Med. Chem., 35, 83 (1992).
  39. W. J. Greenlee and Peter K. S. Siegl. Angiotensin / Renin Modulators, Annual Reports in Medicinal Chemistry, Vol. 27, Chapter 7, pp 59-68 (1992).
  40. P. K. S. Siegl, R. S. L. Chang, N. B. Mantlo, P. K. Chakravarty, W. J. Greenlee, A. A. Patchett, C. S. Sweet and V. J. Lotti. In Vivo Pharmacology of L-158,809, a New Highly Potent and Selective Nonpeptide Angiotensin II (AII) Receptor Antagonist, J. Pharm. Exp. Therapeut., 262, 139, 1992.
  41. R. S. L. Chang, P. K. S. Siegl, B. V. Clineschmidt, N. B. Mantlo, P. K. Chakravarty, W. J. Greenlee, A. A. Patchett and V. J. Lotti. In Vitro Pharmacology of L-158,809, a New Highly Potent and Selective Nonpeptide Angiotensin II (AII) Receptor Antagonist, J. Pharm. Exp. Therapeut., 262, 133, 1992.
  42. W. T. Ashton, C. L. Cantone, R. L. Tolman, W. J. Greenlee, R. J. Lynch, T. W. Schorn, J. F. Strouse and P. K. S. Siegl. Renin Inhibitors With C-Termini Derived from Amides and Esters of -Mercaptoalkanoic Acids, J. Med. Chem., 35, 2772 (1992).
  43. R. A. Rivero, P. K. Chakravarty, R. Chen, W. J. Greenlee, A. Rosegay and R. Simpson, The Synthesis of [3H]-losartan, [3H]-L-158,641 and [3H]-L-158,809. Bioorganic Med. Chem. Letts., 3, 557 (1993).
  44. Eric E. Allen, Stephen E. deLaszlo, Song X. Huang, Carol S. Quagliato, William J. Greenlee, Raymond, Tsing-Bau Chen, Kristie A. Faust, V. J. Lotti, Quinazolinones 1: Design and Synthesis of Potent Quinazolinone-Containing AT1-Selective Angiotensin II Receptor Antagonists, Bioorg. Med. Chem. Letts., 3, 1293 (1993).
  45. Stephen E. de Laszlo, Eric E. Allen, Carol S. Quagliato, William J. Greenlee, Arthur A. Patchett, Robert B. Nachbar, Peter K. S. Siegl, Raymond S. Chang, Salah D. Kivlighn, Terry S. Schorn, Kristie A. Faust, Tsing-Bau Chen, Gloria J. Zingaro, Victor J. Lotti, Quinazolinones 2: QSAR and In Vivo Characterization of AT1-Selective AII Antagonists, Bioorg. Med. Chem. Letts., 3, 1299 (1993).
  46. Theresa M. Williams, Terrence C. Ciccarone, Suzanne C. MacTough, Clarence S. Rooney, Suresh K. Balani, Jon H. Condra, Emilio A. Emini, Mark E. Goldman, William J. Greenlee, Laura R. Kauffman, Julie A. O’Brien, Vinod V. Sardana, William A. Schleif, Anthony D. Theoharides, and Paul S. Anderson. 5-Chloro-3-(phenylsulfonyl)indole-2-carboxamide: A Novel, Non-Nucleoside Inhibitor of HIV-1 Reverse Transcriptase, J. Med. Chem., 36, 1291 (1993).
  47. Linda L. Chang, Wallace T. Ashton, Kelly L. Flanagan, Robert A. Strelitz, Malcolm MacCoss, William J. Greenlee, Raymond S. L. Chang, Victor J. Lotti, Kristie A. Faust, Tsing-Bau Chen, Patricia Bunting, Gloria J. Zingaro, Salah D. Kivlighn and Peter K. S. Siegl. Triazolinones as Nonpeptide Angiotensin II Antagonists. 1. Synthesis and Evaluation of Potent 2,4,5-Trisubstituted Triazolinones, J. Med. Chem., 36, 2558 (1993).
  48. W. T. Ashton, S. M. Hutchins, W. J. Greenlee, G. A. Doss, R. S. L. Chang, V. J. Lotti, K. A. Faust, T.-B. Chen, G. J. Zingaro, S. D. Kivlighn and P. K. S. Siegl. Nonpeptide Angiotensin II Antagonists Derived From 1H-Pyrazole-5-carboxylates and 4-Aryl-1H-imidazole-5-carboxylates, J. Med. Chem., 36, 3595 (1993).
  49. Peter K. S. Siegl, and William J. Greenlee. Challenges and Progress Toward the Development of Orally Active Renin Inhibitors, Curr. Opin. Invest. Drugs, 2, 931 (1993).
  50. M. T. Wu, T. J. Ikeler, W. T. Ashton, R. S. L. Chang, V. J. Lotti and W. J. Greenlee. Synthesis and Structure-Activity Relationships of a Novel Series of Non-peptide AT2 Selective Angiotensin II Receptor Antagonists, Bioorg. Med. Chem. Letts., 3, 2023 1993.
  51. S. E. de Laszlo, C. S. Quagliato, W. J. Greenlee, A. A. Patchett, R. S. L. Chang, V. J. Lotti, T. B. Chen, S. A. Scheck, K. A. Faust, S. D. Kivlighn, T. S. Schorn, G. J. Zingaro and P. K. S. Siegl. L-159,689, a Potent, Orally-active, Balanced Affinity Antagonist of the Angiotensin II AT1 and AT2 Receptors, J. Med. Chem., 36, 3207 (1993).
  52. Sander G. Mills, Mu Tsu Wu, Malcolm MacCoss, Richard J. Budhu, Conrad P. Dorn, Jr., Margaret A. Cascieri, Sharon Sadowski, Catherine D. Strader, William J. Greenlee, 1,4-Diacylpiperazine-2-(S)-[N-Aminoalkyl)carboxamides] as Novel, Potent Substance P Receptor Antagonists, Bioorg. Med. Chem. Letts., 3, 2707 (1993).
  53. Lihu Yang, Ann E. Weber, William J. Greenlee and Arthur A. Patchett, Marcocyclic Renin Inhibitors: Synthesis of a Subnanomolar, Orally Active Cysteine Derived Inhibitor, Tetrahedron Letts., 34, 7035 (1993).
  54. D. S. Dhanoa, S. W. Bagley, R. S. L. Chang, V. J. Lotti, T.-B. Chen, S. D. Kivlighn, G. J. Zingaro, P. K. S. Siegl, P. K. Chakravarty, A. A. Patchett, W. J. Greenlee, (Dipropylphenoxy)phenylacetic Acids: A New Generation of Nonpeptide Angiotensin II Receptor Antagonists, J. Med. Chem., 36, 3738 (1993).
  55. D. S. Dhanoa, S. W. Bagley, R. S. L. Chang, V. J. Lotti, T.-B. Chen, S. D. Kivlighn, G. J. Zingaro, P. K. S. Siegl, A. A. Patchett and W. J. Greenlee, Non-Peptide Angiotensin II Receptor Antagonists. 1. Design, Synthesis and Biological Activity of N-Substituted Indoles and Dihydroindoles, J. Med. Chem., 36, 4230 (1993).
  56. D. S. Dhanoa, S. W. Bagley, R. S. L. Chang, V. J. Lotti, T.-B. Chen, S. D. Kivlighn, G. J. Zingaro, P. K. S. Siegl, P. K. Chakravarty, A. A. Patchett, W. J. Greenlee, Non-Peptide Angiotensin II Receptor Antagonists. 2. Design, Synthesis and Biological Activity of N-Substituted (Phenylamino)phenylacetic Acids and Acylsulfonamides, J. Med. Chem., 36, 4239 (1993).
  57. Nathan B. Mantlo, Dooseop Kim, Debra Ondeyka, Raymond S. L. Chang, Salah D. Kivlighn, Peter K. S. Siegl and William J. Greenlee, Potent Imidazo[4,5-b]pyridine Angiotensin II Antagonists Which Exhibit Balanced Affinity to the AT1 and AT2 Receptor Subtypes, Bioorg. Med. Chem. Letts., 4, 17 (1994).
  58. D. Kim, N. B. Mantlo, R. S. L. Chang, S. D. Kivlighn and W. J. Greenlee, Evaluation of Heterocyclic Acid Equivalents as Tetrazole Replacements in Imidazopyridine-Based Nonpeptide Angiotensin II Receptor Antagonists, Bioorg. Med. Chem. Letts., 4, 41 (1994).
  59. Elizabeth M. Naylor, Prasun K. Chakravarty, Colleen A. Costello, Raymond S. Chang, Tsing-Bau Chen, Kristie A. Faust, Victor J. Lotti, Salah D. Kivlighn, Gloria J. Zingaro, Peter K. S. Siegl, Pancras C. Wong, David J. Carini, Ruth R. Wexler, Arthur A. Patchett and William J. Greenlee. Potent Imidazole Angiotensin II Antagonists: Acylsulfonamides and Acylsulfamides as Tetrazole Replacements, Bioorg. Med. Chem. Letts., 4, 69 (1994).
  60. P. K. Chakravarty, R. A. Strelitz, T.-B. Chen, R. S. L. Chang, V. J. Lotti, G. J. Zingaro, T. W. Schorn, S. D. Kivlighn, P. K. S. Siegl, A. A. Patchett, W. J. Greenlee, Quinazolinone Biphenyl Acylsulfonamides: A Potent New Class of Angiotensin-II Receptor Antagonists, Bioorg. Med. Chem. Letts., 4, 75 (1994).
  61. T. W. Glinka, S. E. de Laszlo, P. K. S. Siegl, R. S. L. Chang, S. D. Kivlighn, T. S. Schorn, K. A. Faust, T. B. Chen, G. J. Zingaro, V. J. Lotti and W. J. Greenlee. A New Class of Balanced AT1/AT2 Angiotensin II Antagonists: Quinazolinone AII Antagonists with Acylsulfonamide and Sulfonylcarbamate Acidic Functionalities, Bioorg. Med. Chem. Letts., 4, 81 (1994).
  62. L. L. Chang, W. T. Ashton, K. L. Flanagan, E. M. Naylor, P. K. Chakravarty, A. A. Patchett, W. J. Greenlee, T.-B. Chen, K. A. Faust, L. W. Schaffer, T. W. Schorn, G. J. Zingaro, R. S. L. Chang, V. J. Lotti, S. D. Kivlighn and P. K. S. Siegl. Triazolinones as Nonpeptide Angiotensin II Antagonists. II. Discovery of a Potent and Orally-Active Triazolinone Acylsulfonamide, Bioorg. Med. Chem. Letts., 4, 115 (1994).
  63. N. J. Kevin, R. A. Rivero, W. J. Greenlee, R. S. L. Chang and T. B. Chen, Substituted Phenylthiophene Benzoylsulfonamides with Potent Binding Affinity to Angiotensin II AT1 and AT2 Receptors, Bioorg. Med. Chem. Letts., 4, 189 (1994).
  64. D. Kim, N. B. Mantlo, J. R. Tata, K. Fitch, D. Dhanoa, K. Owens, D. Levorse, P. K. S. Siegl, R. S. L. Chang, T. Chen, S. Scheck, G. J. Zingaro, S. D. Kivlighn and W. J. Greenlee, Acidic Phenol: A New Class of Potent Nonpeptide Angiotensin II Receptor Antagonists, Bioorg. Med. Chem. Letts., 4, 207 (1994).
  65. Thomas F. Walsh, Kenneth J. Fitch, Malcolm MacCoss, Raymond S. L. Chang, Salah D. Kivlighn, Victor J. Lotti, Peter K. S. Siegl, Arthur A. Patchett and William J. Greenlee, Synthesis of New Imidazo[1,2-b]pyridazine Isosteres of Potent, Imidazo[4,5-b]pyridine Angiotensin II Antagonists, Bioorg. Med. Chem. Letts., 4, 219 (1994).
  66. R. A. Rivero, W. J. Greenlee, R. S. L. Chang, Substituted 1,3-Benzodioxole and 1,3-Benzodithiole-2-carboxylates and Their Tetrazole Analogs with Potent Binding Affinity to the Angiotensin II AT1 Receptor, Bioorg. Med. Chem. Letts., 4, 747 (1994).
  67. Thomasz W. Glinka, Stephen E. de Laszlo, Jennifer Tran, Raymond S. Chang, Tsing-Bau Chen, Victor J. Lotti and William J. Greenlee, L-161,638, A Potent Selective Quinazolinone Angiotensin II Binding Inhibitor, Bioorg. Med. Chem. Letts., 4, 1479 (1994).
  68. D. S. Dhanoa, S. W. Bagley, R. S. L. Chang, V. J. Lotti, T. Chen, S. D. Kivlighn, G. J. Zingaro, P. K. S. Siegl and W. J. Greenlee, Nonpeptide Angiotensin II (AII) Receptor Angtagonists, N-Substituted Indole, Dihydroindole, Phenylaminophenylacetic Acid and Acylsulfonamide-Based AII Receptor Antagonists, in Peptides, Chemistry, Structure and Biology, Proceedings of the Thirteenth American Peptide Symposium, Robert S. Hodges and John A. Smith, eds., Escom Science Publishers, B. V., Leiden, 1994, p. 296.
  69. R. S. L. Chang, R. J. Bendesky, T. B. Chen, K. A. Faust, P. J. Kling, S. A. O’Malley, E. M. Naylor, P. K. Chakravarty, A. A. Patchett, W. J. Greenlee, B. V. Clineschmidt and V. J. Lotti, In Vitro Pharmacology of MK-996, A New Potent And Selective Angiotensin II (AT1) Receptor Antagonist, Drug Dev. Res., 32, 161 (1994).
  70. Thomasz W. Glinka, Stephen E. de Laszlo, Peter K. S. Siegl, Raymond S. Chang, Salah D. Kivlighn, Terry S. Schorn, Kristie A. Faust, Tsing-Bau Chen, Gloria J. Zingaro, Victor J. Lotti and William J. Greenlee, Development of Angiotensin II Antagonists with Equipotent Affinity for Human AT1 and AT2 Receptor Subtypes, Bioorg. Med. Chem. Letts., 4, 2337 (1994).
  71. L. L. Chang, W. T. Ashton, K. L. Flanagan, T. B. Chen, S. O’Malley, G. Zingaro, P. K. Siegl, S. D. Kivlighn, R. S. L. Chang and W. J. Greenlee, Triazolinone Biphenylacylsulfonamides as Angiotensin II Receptor Antagonists With High Affinity For Both The AT1 and AT2 Subtypes, J. Med. Chem., 37, 4464 (1994).
  72. L. L. Chang, W. T. Ashton, K. L. Flanagan, R. A. Rivero, T.-B. Chen, S. S. O’Malley, G. J. Zingaro, S. D. Kivlighn, P. K. S. Siegl, V. J. Lotti, R. S. L. Chang and W. J. Greenlee, Potent Triazolinone-Based Angiotensin II Receptor Antagonists with Equivalent Affinity for Both the AT1 and AT2 Subtypes, Bioorg. Med. Chem. Letts., 4, 2787 (1994).
  73. Prasun K. Chakravarty, Elizabeth M. Naylor, Anna Chen, Raymond S. L. Chang, Tsing-Bau Chen, Kristie A. Faust, Victor J. Lotti, Salah D. Kivlighn, Robert A. Gable, Gloria J. Zingaro, Terry W. Schorn, Linda W. Schaffer, Theodore P. Broten, Peter K. S. Siegl, Arthur A. Patchett and William J. Greenlee, MK-996 (L-159,282), A Highly Potent, Orally Active Imidazo[4,5-b]Pyridine Biphenyl Acylsulfonamide: A New AT1 Selective Angiotensin II Receptor Antagonist, J. Med. Chem., 37, 4068 (1994).
  74. Siv A. Hjorth, Hans T. Schambye, William J. Greenlee and Thue W. Schwartz, Identification of Peptide Binding Residues in the Extracellular Domains of the AT1 Receptor, J. Biol. Chem., 269, 30953 (1994).
  75. Kristine Prendergast, Kym Adams, William J. Greenlee, Robert B. Nachbar, Arthur A. Patchett and Dennis J. Underwood, Derivation of a 3D Pharmacophore Model for the Angiotensin-II Site One Receptor, J. Comput-Aided Mol. Design, 8, 491 (1994).
  76. Dennis J. Underwood, Ralph Rivero, William Greenlee, Arthur Patchett and Kristine Prendergast, Structural Model of Antagonist and Agonist Binding to the Angiotensin-II, AT1 Subtype, G-Protein Coupled Receptor, Chemistry and Biology, Chemistry & Biology, 1, 211 (1994).
  77. Signe Perlman, Hans T. Schambye, Ralph A. Rivero, William J. Greenlee, Siv A. Hjorth and Thue W. Schwartz, Non-peptide Angiotensin Agonist, J. Biol. Chem., 270, 1493 (1995).
  78. Salah D. Kivlighn, Gloria J. Zingaro, Robert A. Gabel, Theodore P. Broten, Terry W. Schorn, Linda W. Schaffer, Elizabeth M. Naylor, Prasun K. Chakravarty, Arthur A. Patchett, William J. Greenlee and Peter K. S. Siegl, In Vivo Pharmacology of a Novel AT1 Selective Angiotensin II Receptor Antagonist, Am. J. Hypertens., 8, 58 (1995).
  79. K. J. Fitch, T. F. Walsh, A. A. Patchett, R. S. L. Chang, P. K. S. Siegl, K. A. Faust, T. B. Chen, V. J. Lotti, S. D. Kivlighn, G. J. Zingaro and W. J. Greenlee, Bioorg. Med. Chem. Letts., 5, 155 (1995).
  80. Salah D. Kivlighn, Gloria J. Zingaro, Ralph A. Rivero, William R. Huckle, Victor J. Lotti, Raymond S. L. Chang, Terry W. Schorn, Nancy Kevin, Robert G. Johnson, Jr., William J. Greenlee and Peter K. S. Siegl, Discovery of L-162,313: A Nonpeptide That Mimics the Biological Actions of Angiotensin-II, Am. J. Physiol, 268, R820 (1995).
  81. T. F. Walsh, K. J. Fitch, R. S. L. Chang, K. A. Faust, T.-B. Chen, S. D. Kivlighn, G. J. Zingaro, V. J. Lotti, P. K. S. Siegl, A. A. Patchett, and W. J. Greenlee, -Phenoxyphenylacetic Acid Derived Angiotensin II Antagonists With Low Nanomolar AT1/ AT2 Receptor Subtype Affinity (Part II), Bioorg. Med. Chem. Letts., 5, 1151 (1995).
  82. T. F. Walsh, K. J. Fitch, D. L. Williams, K. L. Murphy, N. A. Nolan, D. J. Pettibone, R. S. L. Chang, S. O’Malley, B. V. Clineschmidt, D. F. Veber, W. J. Greenlee, Potent, Dual Antagonists of Endothelin and Angiotensin II Receptors Derived From α-Phenoxyphenylacetic Acids (Part III), Bioorg. Med. Chem. Letts., 5, 1155 (1995).
  83. W. T. Ashton, L. L. Chang, K. L. Flanagan, N. B. Mantlo, D. L. Ondeyka, D. Kim, S. E. de Laszlo, T. W. Glinka, R. A. Rivero, N. J. Kevin, R. S. L. Chang, P. K. S. Siegl, S. D. Kivligh, W. J. Greenlee, AT1/AT2-Balanced Angiotensin II Antagonists, Eur. J. Med. Chem., 30 (Suppl.), 255S, 1995.
  84. S. E. de Laszlo, R. S. Chang, T.-B. Chen, K. A. Faust, W. J. Greenlee, S. D. Kivlighn, V. J. Lotti, S. S. O’Malley, T. W. Schorn, P. K. S. Siegl, J. Tran and G. J. Zingaro, The SAR of 6-(N-Alkyl-N-Acyl)-2-Propyl-3-[(2-Tetrazol-5-yl)bipheny-4-yl)methyl]-Quinazolinones as Balanced Affinity Antagonists of the Human AT1 and AT2 Receptors, Bioorg. Med. Chem. Letts., 5, 1359 (1995).
  85. R. A. Rivero, W. J. Greenlee, P. D. Williams, G. R. Kieczykowski and D. L. Williams Jr., Discovery of Substituted 8,9-Dicarboxydibenzo [2,3:5,6] Bicyclo [5.2.0] Nonan-4-ones with Moderate Binding Affinity to the Endothelin ETA and ETB Receptors, Bioorg. Med. Chem. Letts., 5, 1401 (1995).
  86. R. A. Gabel, S. D. Kivlighn, G. J. Zingaro, T. W. Schorn, L. W. Schaffer, W. T. Ashton, L. L. Chang, K. Flanagan, W. J. Greenlee and P. K. S. Siegl, In Vivo Pharmacology of L-159,913, A New Highly Potent and Selective Nonpeptide Angiotensin II Receptor Antagonist, Clin. Exper. Hypertens., 17, 931 (1995).
  87. R. S. L. Chang, V. J. Lotti, T.-B. Chen, K. A. Faust, P. J. Kling, S. A. O’Malley, S. D. Kivlighn, P. K. S. Siegl, D. Ondeyka, W. J. Greenlee, N. B. Mantlo, In Vitro Pharmacology of an Angiotensin AT1 Receptor Antagonist with Balanced Affinity for Angiotensin AT2 Receptors, Eur. J. Pharmacol., 294, 429 (1995).
  88. S. D. Kivlighn, G. J. Zingaro, R. A. Gabel, T. P. Broten, R. S. L. Chang, D. L. Ondeyka, N. B. Mantlo, R. E. Gibson, W. J. Greenlee, P. K. Siegl, In Vivo Pharmacology of an Angiotensin AT1 Receptor Antagonist with Balanced Affinity for Angiotensin AT2 Receptors, Eur. J. Pharmacol., 294, 439 (1995).
  89. L. L. Chang, W. J. Greenlee, Angiotensin II Receptor Antagonists: Nonpeptides with Equivalent High Affinity for Both the AT1 and AT2 Subtypes, Curr. Pharm. Des., 1, 407 (1995).
  90. D. L. Williams, Jr., K. L. Murphy, N. A. Nolan, J. A. O’Brien, D. J. Pettibone, S. D. Kivlighn, S. M. Krause, E. V. Lis, Jr., G. J. Zingaro, R. A. Gabel, F. C. Clayton, P. K. S. Siegl, K. Zhang, J. Naue, K. Vyas, T. F. Walsh, F. K. Fitch, P. K. Chakravarty, W. J. Greenlee and B. V. Clineschmidt, Pharmacology of L-754,142, a Highly Potent, Orally Active, Nonpeptidyl Endothelin Antagonist, J. Pharmacol. Exp. Therapeut., 275, 1518 (1995).
  91. R. R. Wexler, W. J. Greenlee, J. D. Irvin, M. R. Goldberg, K. Prendergast, R. D. Smith, P. B. M. W. M. Timmermans, Nonpeptide Angiotensin II Receptor Antagonists: The Next Generation in Antihypertensive Therapy, J. Med. Chem., 39, 625 (1996).
  92. W. Huckle, M. D. Drag, W. R. Acker, M. Powers, R. C. McFall, D. J. Holder, T. Fujita, I. I. Stabilito, D. Kim, D. L. Ondeyka, N. B. Mantlo, R. S. L. Chang, C. F. Reilly, R. S. Schwartz, W. J. Greenlee, R. G. Johnson, Effects of Subtype-Selective and Balanced Angiotensin II Receptor Antagonists in a Porcine Coronary Artery Model of Vascular Restenosis, Circulation, 93, 1009 (1996).
  93. R. A. Rivero, N. J. Kevin, S. D. Kivlighn, G. J. Zingaro, R. S. Chang and W. J. Greenlee, L-162,389: A Potent Orally Active Angiotensin II Receptor Antagonist with Balanced Affinity to Both AT1 and AT2 Receptor Subtypes, Bioorg. Med. Chem. Letts., 6, 307 (1996).
  94. S. E. de Laszlo, T. W. Glinka, W. J. Greenlee, R. Ball, R. B. Nachbar and K. Prendergast, The Design, Binding Affinity Prediction and Synthesis of Macrocyclic Angiotensin II AT1 and AT2 Receptor Antagonists, Bioorg. Med. Chem. Letts., 6, 923 (1996).
  95. D. L. Williams, Jr., K. L. Murphy, N. A. Nolan, J. A. O’Brien, E. V. Lis, Jr., D. J. Pettibone, B. V. Clineschmidt, S. M. Krause, D. F. Veber, E. M. Naylor, P. K. Chakravarty, T. F. Walsh, D. M. Dhanoa, A. Chen, S. W. Bagley, K. J. Fitch and W. J. Greenlee, Pharmacology of L-744,453, A Novel Nonpeptidyl Endothelin Antagonist, Life Sci., 58, 1149 (1996).
  96. Signe Perlman, Claudio M. Costa-Neto, Ayumi A. Miyakawa, Hans T. Schambye, Siv. A. Hjorth, Antonio C. M. Paiva, Ralph A. Rivero, William J. Greenlee and Thue W. Schwartz, Dual Agonistic and Antagonistic Property of Nonpeptide Angiotensin AT1 Ligands: Susceptibility to Receptor Mutations, Mol. Pharmacol., 51:301 (1997).
  97. S. E. de Laszlo, E. E. Allen, B. Li, D. Ondeyka, R. Rivero, L. Makowitz, C. Molineaux, S. J. Siliciano, M. S. Springer, W. J. Greenlee and N. Mantlo, A Nonpeptide Agonist Ligand of the C5a Receptor: Synthesis, Binding Affinity, Optimization and Functional Characterization, Bioorg. Med. Chem. Letts., 7, 213 (1997).
  98. Stephen M. Krause, Thomas F. Walsh, William J. Greenlee, Robert Ranaei, David L. Williams, Jr. and Salh D. Kivlighn, Renal Protection by a Dual ETA/ETB Endothelin Antagonist, L-754,142, after Aortic Cross-Clamping in the Dog, J. Am. Soc. Nephrol., 8: 1061 (1997).
  99. W. J. Greenlee, Hypertension – Treatment by Blockade of the Renin-Angiotensin System, Proceedings, XIVth International Symposium on Medicinal Chemistry, F. Awouters, Ed., Eur. J. Med. Chem., 32 (Suppl.), 97S, 1997.
  100. William Greenlee and Manoj Desai, Editorial Overview, Current Opinion in Drug Discovery and Development, 1, 3 (1998).
  101. William J. Greenlee and Major Desai, The Chemistry of Drug Design and Lead Optimization, Editorial Overview, Current Opinion in Drug Discovery and Development, 2, 264 (1999).
  102. Y. Wang, S. Chackalamannil, Z. Hu, J. W. Clader, W. Greenlee, W. Billard, H. Binch, III, R. Crosby V. Ruperto, R. A. Duffy, R. McQuade and J. E. Lachowicz, Design and Synthesis of Piperidine Analogs as Potent and Selective M2 Muscarinic Receptor Antagonists, Bioorg. Med. Chem. Letts., 10, 2247 (2000).
  103. William J. Greenlee and Major Desai, The Chemistry of Drug Design and Lead Optimization, Editorial Overview, Current Opinion in Drug Discovery and Development, 3, 352 (2000).
  104. Yuguang Wang, Samuel Chackalamannil, Wei Chang, William Greenlee, Vilma Ruperto, Ruth A. Duffy, Robert McQuade and Jean E. Lachowicz, Design and Synthesis of Ether Analogues as Potent and Selective M2 Muscarinic Receptor Antagonists, Bioorg. Med. Chem. Letts., 11, 891 (2001).
  105. W. R. Huckle, M. D. Drag, W. R. Acker, M. Powers, R. C. McFall, D. J. Holder, T. F. Walsh, R. S. Schwartz, W. J. Greenlee and R. G. Johnson, Jr., Effects of L-749,329, and ET(A)/ET(B) endothelin receptor antagonist, in a porcine coronary artery injury model of vascular restenosis, Circulation, 103, 1899 (2001).
  106. W. Greenlee, J. Clader, T. Asbertom, S. McCombie, J. Ford, H. Guzik, J. Kozlowski, S. Li, C. Liu, D. Lowe, S. Vice, H. Zhao, G. Zhou, W. Billard, H. Binch, R. Crosby, R. Duffy, J. Lachowicz, V. Coffin, R. Watkins, V. Ruperto, C. Strader, L. Taylor and K. Cox, Muscarinic Agonists and Antagonists in the Treatment of Alzheimer’s Disesase, Il Framaco, 56, 247 (2001).
  107. Craig D. Boyle, Samuel Chackalamannil, John W. Clader, William J. Greenlee, Hubert B. Josien, James J. Kaminski, Joseph A. Kozlowski, Stuart W. McCombie, Dennise V. Nazareno, Jayaram R. Tagat, Yuguang Wang, Guowei Zhou, William Billard, Herbert Binch III, Gordon Crosby, Mary Cohen-Williams, Vicki L. Coffin, Kathleen A. Cox, Diane E. Grotz, Ruth A. Duffy, Vilman Ruperto and Jean E. Lachowicz, Metabolic Stabilization of Benzylidene Ketal M2 Muscarinic Receptor Antagonists via Halonaphthoic Acid Substitution, Bioorg. Med. Chem. Letts., 11, 2311 (2001).
  108. Anandan Palani, Sherry Shapiro, John W. Clader, William J. Greenlee, Kathleen Cox, Julie Strizki, Michael Endres and Bahige M. Baroudy, Discovery of 4-[(Z)-(4-Bromophenyl)ethoxyimino)methyl]-1’-[2,4-dimethyl-3-pyridinyl)carbonyl]-4’-methyl-1,4’-bipiperidine N-Oxide (SCH 351125): An Orally Bioavailable Human CCR5 Antagonist for the Treatment of HIV Infection, J. Med. Chem., 44, 3339 (2001).
  109. Julie M. Strizki, Serena Xu, Nicole E. Wagner, Lisa Wojcik, Jia Liu, Yan Hou, Michael Endres, Anandan Palani, Sherry Shapiro, John W. Clader, William J. Greenlee, Jayaram R. Tagat, Stuart McCombie, Kathleen Cox, Ahmad B. Fawzi, Chuan-Chu Chou, Catherine Pugliese-Sivo, Liza Davies, Mary E. Moreno, David D. Ho, Alexandra Trkola, Cheryl A. Stoddart, John P. Moore, Gregory R. Reyes and Bahige M. Baroudy, SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo, Proc. Natl. Acad. Sci. USA, 98, 12718 (2001).
  110. Yuguang Wang, Samuel Chackalamannil, Zhiyong Hu, Brian A. McKittrick, William Greenlee, Vilma Ruperto, Ruth A. Duffy and Jean E. Lachowicz, Sulfide Analogs as Potent and Selective M2 Muscarinic Receptor Antagonists, Bioorg. Med. Chem. Letts., 12, 1087 (2002).
  111. Anandan Palani, Sherry Shapiro, Hubert Josien, Thomas Bara, John W. Clader, William J. Greenlee, Kathleen Cox, Julie M. Stritzki and Bahige M. Baroudy, Synthesis, SAR, and Biological Evaluation of Oximino-Piperidino-Piperidine Amides. 1. Orally Bioavailable CCR5 Receptor Antagonists with Potent Anti-HIV Activity, J. Med. Chem., 45, 3143 (2002).
  112. Yuguang Wang, Samuel Chackalamannil, Zhiyong Hu, William Greenlee, John Clader, James Kaminski, William Billard, Herbert Binch III, Gordon Crosby, Vilma Ruperto, Ruth A. Duffy, Jean E. Lachowicz, Mary Cohen-Williams, Vicki L. Coffin, Kathleen A. Cox and Diane E. Grotz, Improving Oral Efficacy of CNS Drug Candidates: The Discovery of Highly Orally Efficacious Muscarinic M2 Receptor Antagonists, J. Med. Chem., 45, 5415 (2002).
  113. Yuguang Wang, Samuel Chackalamannil, Zhiyong Hu, Craig D. Boyle, Claire M. Lankin, Yan Xia, Ruo Xu, Theodros Asberom, Dmitri Pissarnitski, Andrew W. Stamford, William J. Greenlee, Jeffrey Skell, Stanley Kurowski, Subbarao Vemulapalli, Jairam Palamandra, Madhu Chintala, Ping Wu, Joyce Myers and Peng Wang, Design and synthesis of xanthine analogues as potent and selective PDE5 inhibitors, Bioorg. Med. Chem. Letts., 12, 3149 (2002).
  114. Manoj C. Desai and William J. Greenlee, Editorial Overview, Chemical Genomics, Pharmacogenomics and Pharmacogenetics, Current Opinion in Drug Discovery and Development, 5, 475 (2002).
  115. Andandan Palani, Sherry Shapiro, John W. Clader, William J. Greenlee, David Blythin, Kathleen Cox, Nicole E. Wagner, Julie Strizki, Bahige M. Baroudy and Niya Dan, Biological Evaluation and Interconversion Studies of Rotamers of SCH 351125, an Orally Bioavailable CCR5 Antagonist, Bioorg. Med. Chem. Letts., 13, 705 (2003).
  116. Andandan Palani, Sherry Shapiro, John W. Clader, William J. Greenlee, Susan Vice, Stuart McCombie, Kathleen Cox, Julie Strizki and Bahige M. Baroudy, Oximino-Piperidino-Piperidine-Based CCR5 Antagonists. Part 2: Synthesis, SAR and Biological Evaluation of Symmetrical Heteroaryl Carboxamides, Bioorg. Med. Chem. Letts., 13, 709 (2003).
  117. Anandan Palani, Sundeep Dugar, John W. Clader, William J. Greenlee, Vilma Ruperto, Ruth A. Duffy and Jean E. Lachowicz, Isopropyl Amide Derivatives of Potent and Selective Muscarinic M2 Receptor Antagonists, Bioorg. Med. Chem. Letts., 14, 1791 (2004).
  118. John W. Clader, William Billard, Herbert Binch, III, Lian-Yong Chen, Gordon Crosby, Jr., Ruth A. Duffy, Jennifer Ford, Joseph A. Kozlowski, Jean E. Lachowicz, Shengjian Li, Charles Liu, Stuart W. McCombie, Susan Vice, Gowei Zhou and William J. Greenlee, Muscarinic M2 Antagonists: Anthranilamide Derivatives With Exceptional Selectivity and In Vivo Activity, Bioorg. Med. Chem. Letts., 14, 319 (2004).
  119. Dmitri Pissarnitski, Theodros Asberom, Craig D. Boyle, Samuel Chackalamannil, Madhu Chintala, John W. Clader, William J. Greenlee, Yueqing Hu, Stanley Kurowski, Joyce Myers, Jairam Palamanda, Andrew W. Stamford, Subbaro Vemulapalli, Yuguang Wang, Peng Wang, Ping Wu, and Ruo Xu, SAR Development of Polycyclic Guanine Derivatives Targeted to the Discovery of a Selective PDE5 Inhibitor for Treatment of Erective Dysfunction, Bioorg. Med. Chem. Letts., 14, 1291 (2004).
  120. Manoj C. Desai and William J. Greenlee, Editorial Overview: Transporter Proteins in Drug Disposition and Uptake, Current Opinion in Drug Design and Development, 7, 395 (2004).
  121. Jing Su, Brian A. McKittrick, Haiqun Tang, Michael Czarniecki, William J. Greenlee, Brian E. Hawes and Kim O’Neill, Discovery of Melanin-Concentrating Hormone Receptor R1 Antagonists Using High-Throughput Synthesis, Bioorg. Med. Chem., 13, 1829 (2005).
  122. Wen-Lian Wu, Duane A. Burnett, Richard Spring, William J. Greenlee, Michelle Smith, Leonard Favreau, Ahmad Fawzi, Hongtao Zhang and Jean E. Lachowicz, Dopamine D1/D5 Receptor Antagonists with Improved Pharmacokinetics: Design, Synthesis, and Biological Evaluationm of Phenol Bioisosteric Analogues of Benzazepine D1/D5 Antagonists, J. Med. Chem., 48, 680 (2005).
  123. Craig D. Boyle, Ruo Xu, Theodros Asberom, Samuel Chackalamannil, John W. Clader, William J. Greenlee, Henry Guzik, Yuequing Hu, Zhiyong Hu, Claire M. Lankin, Dmitri Pissarnitski, Andrew W. Stamford, Yuguang Wang, Jeffrey Skell, Stanley Kurowski, Subbarao Vemulapalli, Jairam Palamanda, Madhu Chintala, Ping Wu, Joyce Myers and Peng Wang, Optimization of Purine Based PDE1/PDE5 Inhibitors to a Potent and Selective PDE5 Inhibitor for the Treatment of Male ED, Bioorg. Med. Chem. Letts., 15, 2365 (2005).
  124. Mark D. McBriar, Henry Guzik, Ruo Xu, Jaroslava Paruchova, Shengjian Li, Anandan Palani, John W. Clader, William J. Greenlee, Brian E. Hawes, Timothy J. Kowalski, Kim O’Neill, Brian Spar and Blair Weig, Discovery of Urea Melanin Concentrating Hormone Receptor Antagonists: Orally Efficacious Antiobesity Therapeutics, J. Med. Chem., 48, 2274 (2005).
  125. William J. Greenlee and Manoj C. Desai, Editorial Overview: The Role of Medicinal Chemists in Drug Discovery, Current Opinion in Drug Design and Development, 8, 419 (2005).
  126. Samuel Chackalamannil, Yan Xia, William J. Greenlee, Martin Clasby, Dario Doller, Hsingan Tsai, Theodros Asberom, Michael Czarniecki, Ho-Sam Ahn, George Boykow, Carolyn Foster, Jacqueline Agans Fantuzzi, Matthew Bryant, Janice Lau, and Madhu Chintala, Discovery of Potent Orally Active Thrombin Receptor (Protease Activated Receptor 1 Antagonists as Novel Antithrombotic Agents, J. Med. Chem., 48, 5884 (2005).
  127. Anandan Palani, Sherry Shapiro, Mark D. McBriar, John W. Clader, William J. Greenlee, Brian Spar, Timothy J. Kowalski, Constance Farley, John Cook, Margaret van Heek, Blair Weig, Kim O’Neill, Michael Graziano and Brian Hawes, Biaryl Ureas as Potent and Orally Efficacious Melanin Concentrating Hormone Receptor 1 Antagonists for the Treatment of Obesity, J. Med. Chem., 48, 4746 (2005).
  128. Anandan Palani, Sherry Shapiro, Mark D. McBriar, John W. Clader, William J. Greenlee, Kim O’Neill and Brian Hawes, Biaryl Diamides as Potent Melanin Concentrating Hormone Receptor 1, Bioorg. Med. Chem. Letts., 15, 5234 (2005).
  129. Ruo Xu, Shengjian Li, Jaroslava Paruchova, Mark D. McBriar, Henry Guzik, Anandan Palani, John W. Clader, Kathleen Cox, William J. Greenlee, Brian E. Hawes, Timothy J. Kowalski, Kim O’Neill, Brian D. Spar, Blair Weig and Daniel J. Weston, Bicyclic[4.1.0]heptanes as phenyl replacements for melanin concentrating hormone receptor antagonists, Bioorg. Med. Chem., 14, 3285 (2006).
  130. Martin C. Clasby, Samuel Chackalamannil, Michael Czarniecki, Dario Doller, Keith Eagen, William J. Greenlee, Yan Lin, Hsingan Tsai, Yan Xia, Ho-Sam Ahn, Jacqueline Agans-Fantuzzi, George Boykow, Matthew Bryant, Madhu Chintala, Carolyn Foster and Janice Lau, Discovery and Synthesis of a Novel Series of Quinoline Based Thrombin Receptor (PAR-1) Antagoinsts, Bioorg. Med. Chem. Letts., 16, 1544-1548 (2006).
  131. Wen-Lian Wu, Duane A. Burnett, Mary Ann Caplen,Martin S. Domalski, Chad Bennett, William J. Greenlee, Brian E. Hawes, Kim O’Neill, Blair Weig, Daniel Weston, Brian Spar and Timothy Kowalski, Design and Synthesis of Orally Efficacious Benzimidazoles as Melanin-Concentrating Hormone Receptor 1 Antagonists, Bioorg. Med. Chem. Letts., 16, 3674 (2006).
  132. Wen-Lian Wu, Duane A. Burnett, Richard Spring, Li Qiang, Thavalakulamgara K. Sasikumar, Martin S. Domalski, William J. Greenlee, Kim O’Neill and Brian E. Hawes, Synthesis and Structure–Activity Relationships of Piperidine-Based Melanin-Concentrating Hormone Receptor 1 Antagonists, Bioorg. Med. Chem. Letts., 16, 3668 (2006).
  133. Yan Xia, Samuel Chackalamannil, Tze-Ming Chan, Michael Czarniecki, Dario Doller, Keith Eagen, William J. Greenlee, Hsingan Tsai, Yuguang Wang, Ho-Sam Ahn, George C. Boykow and Andrew T. McPhail, Himbacine derived thrombin receptor (PAR-1) antagonists: Structure–activity relationship of the lactone ring, Bioorg. Med. Chem. Letts., 16, 4969 (2006).
  134. Bernard R. Neustadt, Jinsong Hao, Neil Lindo, William J. Greenlee, Andrew W. Stamford, Ennio Ongini, John Hunter, Angela Monopoli, Rosalia Bertorelli, Carolyn Foster, Leyla Arik, Jean Lachowicz, Kwokei Ng and Kung-.I Feng, Potent, Selective and Orally Active Adenosine A2A Receptor Antagonists: Arylpiperazine Derivatives of Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines, Bioorg. Med. Chem. Letts., 17, 1376 (2007).
  135. T.K. Sasikumar, Li Qiang, Duane A. Burnett, William J. Greenlee, Brian E. Hawes, Timothy J. Kowalski, Kim O’Neill, Brian D. Spar and Blair Weig, Novel aminobenzimidazoles as selective MCH-R1 antagonists for the treatment of metabolic diseases, Bioorg. Med. Chem. Letts., 16, 5427-5431 (2006).
  136. T.K. Sasikumar, L. Qiang, W.-L. Wu, D.A. Burnett, W.J. Greenlee, K. O’Neill, B.E. Hawes, M. van Heek and M. Graziano, Tetrahydroisoquinolines as MCH-R1 antagonists, Bioorg. Med. Chem. Letts., 16, 4917-4921 (2006).
  137. Mark D. McBriar, Henry Guzik, Sherry Shapiro, Jaroslava Paruchova, Ruo Xu, Anandan Palani, John W. Clader, Kathleen Cox, William J. Greenlee, Brian E. Hawes, Timothy J. Kowalski, Kim O’Neill, Brian Spar, Blair Weg, Daniel J. Weston, Constance Farley and John Cook, Discovery of Orally Efficacious Melanin Concentrating Hormone-1 Receptor Antagonists as Antiobesity Agents. Synthesis, SAR and Biological Evaluation of Bicyclo[3.1.0]hexyl Ureas, J. Med. Chem., 49, 2294 (2006).
  138. Theodros Asberom, Thomas A. Bara, John W. Clader, William J. Greenlee, Henry S. Guzik, Hubert B. Josien, Wei Li, Eric M. Parker, Dmitri A. Pissarnitski, Lixin Song Lili Zhang and Zhiqiang Zhao, Tetrahydroquinoline sulfonamides as λ-secretase inhibitors, Bioorg. Med. Chem. Letts., 17, 205 (2007).
  139. Theodros Asberom, Zhiqiang Zhao, Thomas A. Bara, John W. Clader, William J. Greenlee, Lynn A. Hyde, Hubert B. Josien, Wei Li, Andrew T. McPhail, Amin A. Nomeir, Eric M. Parker, Murali Rajagopalan, Lixin Song, Gwendolyn T. Wong, Lili Zhang, Qi Zhang, Dmitri A. Pissarnitski, Discovery of λ-secretase inhibitors efficacious in a transgenic animal model of alzheimer’s disease, Bioorg. Med. Chem. Letts., 17, 511 (2007).
  140. Dmitri A. Pissarnitski,, Theodros Asberom, Thomas A. Bara, Alex V. Buevich, John W. Clader, William J. Greenlee, Henry S. Guzik, Hubert B. Josien, Wei Li, Michael McEwan, Brian A. McKittrick, Terry L. Nechuta, Eric M. Parker,Lisa Sinning, Elizabeth M. Smith, Lixin Song, Henry A. Vaccaro, Johannes H. Voigt, Lili Zhang, Qi Zhang and Zhiqiang Zhao, 2,6-Disubstituted N-arylsulfonyl piperidinesas λ-secretase inhibitors, Bioorg. Med. Chem. Letts., 17, 57 (2007).
  141. Martin C. Clasby, Samuel Chackalmannil, Michael Czarniecki, Dario Doller, Keith Eagen, William Greenlee, Grace Kao, Yan Lin, Hsingan Tsai, Yan Xia, Ho-Sam Ahn, Jacqueline Agans-Fantuzzi, George Boykow, Madhu Chintala, Carolyn Foster, April Smith-Thoran, Kevin Alton3, Matthew Bryant, Yunsheng Hsieh, Janice Lau, and Jairam Palamanda, Metabolism-based identification of a potent thrombin receptor antagonist, J. Med. Chem., 50, 129 (2007).
  142. Tao Guo, Rachael C. Hunter, Rui Zhang and William J. Greenlee, Microwave assisted synthesis of isothiazolo-, thiazolo-, imidazo-,and pyrimido-pyrimidinones as novel MCH1R antagonists, Tetrahedron Letts., 48, 613–615 (2007).
  143. Silverman, Lisa S.; Caldwell, John P.; Greenlee, William J.; Kiselgof, Eugenia; Matasi, Julius J.; Tulshian, Deen B.; Arik, Leyla; Foster, Carolyn; Bertorelli, Rosalia; Monopoli, Angela; Ongini, Ennio. 3H-[1,2,4]-Triazolo[5,1-i]purin-5-amine derivatives as adenosine A2A antagonists, Bioorg. Med. Chem. Letts., 17, 1659-1662 (2007)
  144. Hubert Josien, Thomas Bara, Murali Rajagopalan, Theodros Asberom, John W. Clader, Leonard Favreau, William J. Greenlee, Lynn A. Hyde, Amin A. Nomeir, Eric M. Parker, Dmitri A. Pissarnitski, Lixin Song, Gwendolyn T. Wong, Lili Zhang, Qi Zhang and Zhiqiang Zhao, Small Conformationally Restricted Piperidine N-arylsulfonamides as Orally Active λ-Secretase Inhibitors, Bioorg. Med. Chem. Letts., 17, 5330 (2007)
  145. Martin C. Clasby, Samuel Chackalmannil, Michael Czarniecki, Dario Doller, Keith Eagen, William Greenlee, Yan Lin, Jayaram R. Tagat, Hsingan Tsai, Yan Xia, Ho-Sam Ahn, Jacqueline Agans-Fantuzzi, George Boykow, Madhu Chintala, Yunsheng Hsieh, Janice Lau, and Andrew T. McPhail, Himbacine-Derived Thrombin Receptor Antagonists: Discovery of a New Tricyclic Core, Bioorg. Med. Chem. Letts., 17, 3647–3651 (2007).
  146. Ginny D. Ho, Ana Bercovici, Deen Tulshian, William J. Greenlee, Ahmad Fawzi,April Smith Torhan and Hongtao Zhang, Synthesis and structure–activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1, Bioorg. Med. Chem. Letts., 17, 3023 (2007).
  147. Ginny D. Ho, Ana Bercovici, Deen Tulshian, William J. Greenlee, Ahmad Fawzi, Xiomara Fernandez, Robbie L. McLeod, April Smith Torhan and Hongtao Zhang, Synthesis and structure–activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2, Bioorg. Med. Chem. Letts., 17, 3028 (2007).
  148. Jing Su, Brian A. McKittrick, Haiqun Tang, Duane A. Burnett, John W. Clader, William J. Greenlee, Brian E. Hawes, Kim O_Neill, Brian Spar, Blair Weig, Timothy Kowalski, Steve Sorota, Cheng Li and Tongtong Liu, SAR study of bicyclo[4.1.0]heptanes as melanin-concentrating hormone receptor, Bioorg. Med. Chem., 15, 5369 (2007).
  149. Xia, Yan; Chackalamannil, Samuel; Clasby, Martin; Doller, Dario; Eagen, Keith; Greenlee, William J.; Tsai, Hsingan; Agans-Fantuzzi, Jacqueline; Ahn, Ho-Sam; Boykow, George C.; Hsieh, Yunsheng; Lunn, Charles A.; Chintala, Madhu. Himbacine derived thrombin receptor (PAR – 1) antagonists: SAR of the pyridine ring, Bioorg. Med. Chem. Letts., 17, 4509-4513 (2007).
  150. Wen-Lian Wu, Duane A. Burnett, Martin Domalski, William J. Greenlee, Cheng Li, Rosalia Bertorelli, Silva Fredduzzi, Gianluca Lozza, Alessio Veltri and Angelo Reggiani, Discovery of Orally Efficacious Tetracyclic Metabotropic Glutamate Receptor 1 (mGluR1) Antagonists for the Treatment of Chronic Pain, J. Med. Chem., 50, 5550 (2007).
  151. Mariappan V. Chelliah, Samuel Chackalamannil, Yan Xia, Keith Eagen, Martin C. Clasby, Xiaobang Gao, William Greenlee, Ho-Sam Ahn, Jacqueline Agans-Fantuzzi, George Boykow, Yunsheng Hsieh, Matthew Bryant, Jairam Palamanda, Tze-Ming Chan, David Hesk, and Madhu Chintala, Heterotricyclic Himbacine Analogs as Potent, Orally Active Thrombin Receptor (Protease Activated Receptor-1) Antagonists, J. Med. Chem., 50, 5147 -5160, 2007.
  152. Hongmei Li, Theodros Asberom, Thomas A. Bara, John W. Clader, William J. Greenlee, Hubert B. Josien, Mark D. McBriar, Amin Nomeir, Dmitri A. Pissarnitski, Murali Rajagopalan, Ruo Xu, Zhiqiang Zhao, Lixin Song and Lili Zhang, Discovery of 2,4,6-trisubstituted N-arylsulfonyl piperidines as γ-secretase inhibitors, Bioorg. Med. Chem. Letts., 17, 6290-6294 (2007).
  153. Guoqing Li, Andrew W. Stamford, Ying Huang, Kuo–Chi Cheng, John Cook, Constance Farley, Jun Gao, Lorraine Ghibaudi, William J. Greenlee, Mario Guzzi, Margaret van Heek, Joyce J. Hwa, Joe Kelly, Deborra Mullins, Eric M. Parker, Sam Wainhaus and Xiaoping Zhang, Discovery of Novel Orally Active Ureido NPY Y5 Receptor Antagonists, Bioorg. Med. Chem. Letts., 18, 1146 (2008).
  154. Mark D. McBriar, John W. Clader, Inhou Chu, Robert A. Del Vecchio, Leonard Favreau, William J. Greenlee, Lynn A. Hyde, Amin A. Nomeir, Eric M. Parker, Dmitri A. Pissarnitski, Lixin Song, Lili Zhang and Zhiqiang Zhao, Discovery of amide and heteroaryl isosteres as carbamate replacements in a series of orally active γ-secretase inhibitors, Bioorg. Med. Chem. Letts., 18, 215 (2008).
  155. Samuel Chackalamannil, Yuguang Wang, William J. Greenlee, Zhiyong Hu, Yan Xia, Ho-Sam Ahn, George Boykow, Yunsheng Hsieh, Jairam Palamanda, Jacqueline Agans-Fantuzzi, Stan Kurowski, Michael Graziano, and Madhu Chintala, Discovery of a Novel, Orally Active Himbacine-Based Thrombin Receptor Antagonist (SCH 530348) with Potent Antiplatelet Activity, J. Med. Chem., 51, 3061 (2008).
  156. Madhu Chintala, Michael P. Graziano, Samuel Chackalamannil, William Greenlee, Teddy Kosoglou, John Strony, Gail Berman and Enrico Veltri, Thrombin Receptor Antagonist as a Novel Approach for the Treatment of Atherothrombosis, Nature Insight, Cardiovascular Disease, Supplement to Nature, Vol. 451, No. 7181 (2008).
  157. Unmesh Shah, Craig D. Boyle, Samuel Chackalamannil, Bernard R. Neustadt, Neil Lindo, William J. Greenlee, Carolyn Foster, Leyla Arik, Ying Zhai, Kwokei Ng, Shiyong Wang, Angela Monopoli, Jean E. Lachowicz, Biaryl and heteroaryl derivatives of SCH 58261 as potent and selective adenosine A2A receptor antagonists, Bioorg. Med. Chem. Letts., 18, 4199 (2008).
  158. Unmesh Shah, Claire M. Lankin, Craig D. Boyle, Samuel Chackalamannil, William J. Greenlee, Bernard R. Neustadt, Mary E. Cohen-Williams, Guy A. Higgins, Kwokei Ng, Geoffrey B. Varty, Hongtao Zhang, Jean E. Lachowicz, Design, synthesis, and evaluation of fused heterocyclic analogs of SCH 58261 as adenosine A2A receptor antagonists, Bioorg. Med. Chem. Letts., 18, 4204 (2008).
  159. Shu-Wei Yang, Ginny Ho, Deen Tulshian, William J. Greenlee, Xiomara Fernandez, Robbie L. McLeod, Stephen Eckel and John Anthes, Structure–activity relationships of 3-substituted N-benzhydryl-nortropane Analogs as Nociceptin Receptor Ligands for the Treatment of Cough, Bioorg. Med. Chem. Letts., 18, 6340 (2008).
  160. Bernard R. Neustadt, Hong Liu, Jinsong Hao, William J. Greenlee, Andrew W. Stamford, Carolyn Foster, Leyla Arik, Jean Lachowicz, Hongtao Zhang, Rosalia Bertorelli, Silva Fredduzzi, Geoffrey Varty, Mary Cohen-Williams, Kwokei Ng, Potent and selective adenosine A2A receptor antagonists: 1,2,4-Triazolo[1,5-c]pyrimidines, Bioorg. Med. Chem. Letts., 19, 967 (2009).
  161. Shu-Wei Yang, Ginny Ho, Deen Tulshian, William J. Greenlee, Zheng Tan, Hongtao Zhang, April Smith-Torhan, Ahmad Fawzi, John Anthes, Sherry Lu, Geoffrey Varty, Xiomara Fernandez, Robbie L. McLeod, John Hey, Identification of 3-substituted N-benzhydryl-nortropane analogs as nociceptin receptor ligands for the management of cough and anxiety, Bioorg. Med. Chem. Letts., 19, 2482 (2009).
  162. Ginny D. Ho, John Anthes, Ana Bercovici, John P. Caldwell, Kuo-Chi Cheng, Xiaoming Cui, Ahmad Fawzi, Xiomara Fernandez, William J. Greenlee, John Hey, Walter Korfmacher, Sherry X. Lu, Robbie L. McLeod, Fay Ng, April Smith Torhan, Zheng Tan, Deen Tulshian, Geoffrey B. Varty, Xiaoying Xu, Hongtao Zhang, The discovery of tropane derivatives as nociceptin receptor ligands for the management of cough and anxiety, Bioorg. Med. Chem. Letts., 19, 2519 (2009).
  163. T. K. Sasikumar, Li Qiang, Duane A. Burnett, William J. Greenlee, Cheng Li, Larry Heimark, Birendra Pramanik, Mariagrazia Grilli, Rosalia Bertorelli, Gianluca Lozza, Angelo Reggiani, Tricyclic Thienopyridine-pyrimidones/thienopyrimidine-pyrimidones as Orally Efficacious mGluR1 Antagonists for Neuropathic Pain, Bioorg. Med. Chem. Letts., 19, 3199 (2009).
  164. Santhosh F. Neelamkavil, Craig D. Boyle, Samuel Chackalamannil, William J. Greenlee, Lili Zhang, and Giuseppe Terracina, The discovery of azepane sulfonamides as potent 11β-HSD1 inhibitors, Bioorg. Med. Chem. Letts., 19, 4563 (2009).
  165. Zhaoning Zhu, Zhong-Yue Sun, Yuanzan Ye, Brian McKittrick, William Greenlee, Michael Czarniecki, Ahmad Fawzi, Hongtao Zhang and Jean Lachowicz, Design and Discovery of 1,3-Benzodizepines as Novel Dopamine Antagonists, Bioorg. Med. Chem. Letts., 19, 5218 (2009).
  166. Shu-Wei Yang, Ginny Ho, Deen Tulshian, William J. Greenlee, John Anthes, Xiomara Fernandez, Robbie L. McLeod, John A. Hey and Xiaoying Xu, Discovery of Orally Active 3-Pyridinyl-tropane As a Potent Nociceptin Receptor Agonist for the Management of Cough, J. Med. Chem., 52, 5323 (2009).
  167. Hubert Josien, Thomas Bara, Murali Rajagopalan, John W. Clader, William J. Greenlee, Leonard Favreau, Lynn A. Hyde, Amin A. Nomeir, Eric M. Parker, Lixin Song, Lili Zhang, Qi Zhang, Novel orally active morpholine N-arylsulfonamides γ-secretase inhibitors with low CYP 3A4 liability, Bioorg. Med. Chem. Letts., 19, 6032 (2009).
  168. Zhong-Yue Sun, Zhaoning Zhu, Yuanzan Ye, Brian McKittrick, Michael Czarniecki, William Greenlee, Deborra Mullins, Mario Guzzi, Discovery and SAR of cyclic isothioureas as novel NPY Y1 receptor antagonists, Bioorg. Med. Chem. Letts., 19, 6012 (2009).
  169. T.K. Sasikumar, Duane A. Burnett, William J. Greenlee, Michelle Smith, Ahmad Fawzi, Hongtao Zhang, Jean E. Lachowicz, Remote functionalization of SCH 39166: Discovery of potent and selective benzazepine dopamine D1 receptor antagonists, Bioorg. Med. Chem. Letts., 20, 832 (2010).
  170. Li Qiang, T.K. Sasikumar, Duane A. Burnett, Jing Su, Haiqun Tang, Yuanzan Ye, Robert D. Mazzola Jr., Zhaoning Zhu, Brian A. McKittrick, William J. Greenlee, Ahmad Fawzi, Michelle Smith, Hongtao Zhang, Jean E. Lachowicz, Discovery of new SCH 39166 analogs as potent and selective dopamine D1 receptor antagonists, Bioorg. Med. Chem. Letts., 20, 836 (2010).
  171. Ruo Xu, David Cole, Ted Asberom, Tom Bara, Chad Bennett, Duane A. Burnett, John Clader, Martin Domalski, William Greenlee, Lynn Hyde, Hubert Josien, Hongmei Li, Mark McBriar, Brian McKittrick, Andrew T. McPhail, Dmitri Pissarnitski, Li Qiang, Murali Rajagopalan, Thavalakulamgar Sasikumar, Jing Su, Haiqun Tang, Wen-Lian Wu, Lili Zhang, Zhiqiang Zhao, Design and Synthesis of Tricyclic Sulfones as γ-Secretase Inhibitors with Greatly Reduced Notch Toxicity, Bioorg. Med. Chem. Letts., 20, 2591 (2010).
  172. Jack D. Scott, Sarah W. Li, Hongwu Wang, Yan Xia, Charles L. Jayne, Michael W. Miller, Ruth A. Duffy, George C. Boykow, Timothy J. Kowalski, Brian D. Spar, Andrew W. Stamford, Samuel Chackalamannil, Jean E. Lachowicz, William J. Greenlee, Diaryl piperidines as CB1 receptor antagonists, Bioorg. Med. Chem. Letts., 20, 1278 (2010).
  173. Yu-Sen Wang, Corey Strickland, Johannes H. Voigt, Matthew E. Kennedy, Brian M. Beyer, Mary M. Senior, Elizabeth M. Smith, Terry L. Nechuta, Vincent S. Madison, Michael Czarniecki, Brian A. McKittrick, Andrew W. Stamford, Eric M. Parker, John C. Hunter, William J. Greenlee and Daniel F. Wyss, Application of Fragment-Based NMR Screening, X-ray Crystallography, Structure-Based Design, and Focused Chemical Library Design to Identify Novel μM Leads for the Development of nM BACE-1 (β-Site APP Cleaving Enzyme 1) Inhibitors, J. Med. Chem., 53, 942 (2010).
  174. Zhaoning Zhu, Zhong-Yue Sun, Yuanzan Ye, Johannes Voigt, Corey Strickland, Elizabeth M. Smith, Jared Cumming, Lingyan Wang, Jesse Wong, Yu-Sen Wang, Daniel F. Wyss, Xia Chen, Reshma Kuvelkar, Matthew E. Kennedy, Leonard Favreau, Eric Parker, Brian A. McKittrick, Andrew Stamford, Michael Czarniecki, William Greenlee and John C. Hunter, Discovery of Cyclic Acylguanidines as Highly Potent and Selective β-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I—Inhibitor Design and Validation, J. Med. Chem., 53, 951 (2010).
  175. T.K. Sasikumar, Li Qiang, Duane A. Burnett, William J. Greenlee, Cheng Li, Mariagrazia Grilli, Rosalia Bertorelli, Gianluca Lozza, Angelo Reggiani, A-ring Modifications on the Triazafluorenone Core Structure and Their mGluR1 Antagonist Properties, Bioorg. Med. Chem. Letts., 20, 2474 (2010).
  176. Jared Cumming, Suresh Babu, Ying Huang, Carolyn Carrol, Xia Chen, Leonard Favreau, William Greenlee, Tao Guo, Matthew Kennedy, Reshma Kuvelkar, Thuy Le, Guoqing Li, Nansie McHugh, Peter Orth, Lynne Ozgur, Eric Parker, Kurt Saionz, Andrew Stamford, Corey Strickland, Dawit Tadesse, Johannes Voigt, Lili Zhang, Qi Zhang, Piperazine sulfonamide BACE1 inhibitors: Design, synthesis, and in vivo characterization, Bioorg. Med. Chem. Letts., 20, 2837 (2010).
  177. T. K. Sasikumar, Duane A. Burnett, Theodros Asberom, Wen-Lian Wu, Chad Bennett, David Cole, Ruo Xu, William J. Greenlee, John Clader, Lili Zhang, Lynn Hyde, Tetracyclic sulfones as potent γ-secretase inhibitors: Synthesis and structure activity relationship studies, Bioorg. Med. Chem. Letts., Bioorg. Med. Chem. Letts., 20, 3645 (2010).
  178. Xianhai Huang,, Robert Aslanian,, Wei Zhou, Xiaohong Zhu, Jun Qin,William Greenlee, Zhaoning Zhu, Lili Zhang, Lynn Hyde, Inhou Chu, Mary Cohen-Williams, and Anandan Palani, The Discovery of Pyridone and Pyridazone Heterocycles as γ-Secretase Modulators, ACS Med. Chem. Letts., 1, 184 (2010).
  179. T. K. Sasikumar, Li Qiang, Duane A. Burnett, David Cole, Ruo Xu, Hongmei Li, William J. Greenlee, John Clader, Lili Zhang, Lynn Hyde, Tricyclic sulfones as orally active λ-secretase inhibitors: Synthesis and structure–activity relationship studies, Bioorg. Med. Chem. Letts., 20, 3632 (2010).
  180. Elizabeth M. Smith, Steve Sorota, Hyunjin M. Kim, Brian A. McKittrick, Terry L. Nechuta, Chad Bennett, Chad Knutson, Duane A. Burnett, Jane Kieselgof, Zheng Tan, Diane Rindgen, Terry Bridal, Xiaoping Zhou, Yu-Ping Jia, Zoe Dong, Debbie Mullins, Xiaoping Zhang, Tony Priestley, Craig C. Correll, Deen Tulshian, Michael Czarniecki, William J. Greenlee, T-type calcium channel blockers: spiro-piperidine azetidines and azetidinones-optimization, design and synthesis, Bioorg. Med. Chem. Letts., 20, 4602 (2010).
  181. Yan Xia, Samuel Chackalamannil, William J. Greenlee, Yuguang Wang, Zhiyong Hu, Yuriko Root, Jesse Wong, Jianshe Kong, Ho-Sam Ahn, George Boykow, Yunsheng Hsieh, Stan Kurowski and Madhu Chintala, Discovery of a Vorapaxar Analog with Increased Aqueous Solubility, Bioorg. Med. Chem. Letts., 20, 6676 (2010).
  182. Hongmei Li, Ruo Xu, David Cole, John W. Clader, William J. Greenlee, Amin A. Nomeir, Lixin Song, Lili Zhang, Design, synthesis, and structure–activity relationship studies of N-arylsulfonyl morpholines as γ-secretase inhibitors, Bioorg. Med. Chem. Letts., 20, 6606 (2010).
  183. Jun Qin, Pawan Dhondi, Xianhai Huang, Mihirbaran Mandal, Zhiqiang Zhao, Dmitri Pissarnitski, Wei Zhou, Robert Aslanian, Zhaoning Zhu, William Greenlee, John Clader, Lili Zhang, Mary Cohen-Williams, Nicholas Jones, Lynn Hyde, Anandan Palani, Discovery of fused 5,6-bicyclic heterocycles as γ-secretase modulators, Bioorg. Med. Chem. Letts., 21, 664 (2010).
  184. Shu-Wei Yang, Jennifer Smotryski, Julius Matasi, Ginny Ho, Deen Tulshian, William J. Greenlee, Rossella Brusa, Massimiliano Beltramo, Kathleen Cox, Structure–activity relationships of 2,4-diphenyl-1H-imidazole analogs as CB2 receptor agonists for the treatment of chronic pain, Bioorg. Med. Chem. Letts., 21, 182 (2011).
  185. Jing Su, Haiqun Tang, Brian A. McKittrick, Ruo Xu, John W. Clader, William J. Greenlee, Lynn Hyde and Lili Zhang, Synthesis and SAR study of tricyclic sulfones as λ-secretase inhibitors: C-6 and C-8 positions, Bioorg. Med. Chem. Letts., 21, 3447 (2011).
  186. Yan Xia, Samuel Chackalamannil, William J. Greenlee, Charles Jayne, Bernard Neustadt, Andrew Stamford, Henry Vaccaro, Xiaoying (Lucy) Xu, Hana Baker, Kim O’Neill, Morgan Woods, Brian Hawes, Tim Kowalski, Discovery of a nortropanol derivative as a potent and orally active GPR119 agonist for type 2 diabetes, Bioorg. Med. Chem. Letts., 21, 3290 (2011).
  187. Julius J. Matasi, Stephanie Brumfield, Deen Tulshian, Michael Czarnecki, William Greenlee, Charles G. Garlisi, Hongchen Qiu, Kristine Devito, Shu-Cheng Chen, Youngliang Sun, Rosalia Bertorelli, William Geiss, Van-Duc Le, Gregory S. Martin, Samuel A. Vellekoop, James Haber and Melissa L. Allard, Synthesis and SAR development of novel P2X7 receptor antagonists for the treatment of pain: Part 1, Bioorg. Med. Chem. Letts., 21, 3805 (2011).
  188. Jun Qin, Wei Zhou, Xianhai Huang,, Pawan Dhondi, Anandan Palani, Robert Aslanian, Zhaoning Zhu, William Greenlee, Mary Cohen-Williams, Nicholas Jones, Lynn Hyde, and Lili Zhang, Discovery of a Potent Pyrazolopyridine Series of γ-Secretase Modulators, ACS Med. Chem. Letts., 2, 471 (2011).
  189. Stephanie Brumfield, Julius J. Matasi, Deen Tulshian, Michael Czarniecki, William Greenlee, Charles Garlisi, Hongchen Qiu, Kristine Devito, Shu-Cheng Chen, Yongliang Sun, Rosalia Bertorelli, Justin Ansell, William Geiss, Van-Duc Le, Gregory S. Martin, Samuel A. Vellekoop, James Haber, Melissa L. Allard, Synthesis and SAR development of novel P2X7 receptor antagonists for the treatment of pain: Part 2, Bioorg. Med. Chem. Letts., 21, 7287 (2011). 
  190. Zhong-Yue Sun, Theodros Asberom, Thomas Bara, Chad Bennett, Duane A. Burnett, Inhou Chou, John Clader, Mary Cohen-Williams, David Cole, Michael Czarniecki, James Durkin, Gioconda Gallo, William J Greenlee, Hubert Josien, Xianhai Huang, Lynn Hyde, Nicholas Jones, Irina Kazakevich, Hongmei Li, Xiaoxiang Liu, Julie Lee, Malcolm MacCoss, Troy McCracken, Amin Nomeir, Robert Mazzola, Anandan Palani, Eric M. Parker, Dmitri Pissarnitski, Jun Qin, Lixin Song, Giuseppe Terracina, Monica Vicarel, Johannes H. Voigt, Ruo Xu, Lili Zhang, Qi Zhang, Zhiqiang Zhao, Xiaohong Zhu, and Zhaoning Zhu, Cyclic hydroxyamidines as amide isosteres: Discovery of oxadiazolines and oxadiazines as potent and highly efficacious g-secretase modulators in vivo, J. Med. Chem., 55, 489–502 (2012). 
  191. Anandan Palani, Ashwin U. Rao, Xiao Chen, Xianhai Huang, Jing Su, Haiqun Tang, Ying Huang, Jun Qin, Dong Xiao, Sylvia Degrado, Michael Sofolarides, Xiaohong Zhu, Zhidan Liu, Brian McKittrick, Wei Zhou, Robert Aslanian, William J. Greenlee, Mary Senior, Boonlert Cheewatrakoolpong, Hongtao Zhang, Constance Farley, John Cook, Stan Kurowski, Qiu Li, Margaret van Heek, Gangfeng Wang, Yunsheng Hsieh, Fangbiao Li, Scott Greenfeder, and Madhu Chintala, Discovery of SCH 900271, a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia, ACS Med. Chem. Lett., 3, 63–68 (2012). 
  192. Shu-Wei Yang, Jennifer Smotryski, William T. McElroy, Zheng Tan, Ginny Ho, Deen Tulshian, William J. Greenlee, Mario Guzzi, Xiaoping Zhang, Deborra Mullins, Li Xiao, Alan Hruza, Tze-Ming Chan, Diane Rindgen, Carina Bleickardt, Robert Hodgson, Discovery of orally active pyrazoloquinolines as potent PDE10 inhibitors for the management of schizophrenia, Bioorg. Med. Chem. Letts, 22, 235 (2012).
  193. William T. McElroy, Zheng Tan, Kallol Basu, Shu-Wei Yang, Jennifer Smotryski, Ginny D. Ho, Deen Tulshian, William J. Greenlee, Deborra Mullins, Mario Guzzi, Xiaoping Zhang, Carina Bleickardt, Robert Hodgson, Pyrazoloquinolines as PDE10A inhibitors: Discovery of a tool compound, Bioorg. Med. Chem. Letts, 22, 1335 (2012).
  194. Chad E. Bennett, Duane A. Burnett, William J. Greenlee, Chad E. Knutson, Peter Korakas, Cheng Li, Deen Tulshian, Wen-Lian Wu, Rosalia Bertorelli, Silva Fredduzzi, Mariagrazia Grilli, Gianluca Lozza, Angelo Reggiani, Alessio Veltri, Fused tricyclic mGluR1 antagonists for the treatment of neuropathic pain, Bioorg. Med. Chem. Letts, 22, 1575 (2012).
  195. Ginny D. Ho, W. Michael Seganish, Ana Bercovici, Deen Tulshian, William J. Greenlee, Rachel Van Rijn, Alan Hruza, Li Xiao, Diane Rindgen, Deborra Mullins, Mario Guzzi, Xiaoping Zhang, Carina Bleickardt, and Robert Hodgson, The SAR development of dihydroimidazoisoquinoline derivatives as phosphodiesterase 10A inhibitors for the treatment of schizophrenia, Bioorg. Med. Chem. Letts, 22, 2585 (2012).
  196. Mariappan V. Chelliah, Samuel Chackalamannil, Yan Xia, Keith Eagen, William J. Greenlee, Ho-Sam Ahn, Jacqueline Agans-Fantuzzi, George Boykow, Yunsheng Hsieh, Matthew Bryant, Tze-Ming Chan, Madhu Chintala, Discovery of nor-seco himbacine analogs as thrombin receptor antagonists, Bioorg. Med. Chem. Letts, 22, 2544 (2012).
  197. Jared N. Cumming, Elizabeth M. Smith, Lingyan Wang, Jeffrey Misiaszek, James Durkin, Jianping Pan, Ulrich Iserloh, Yusheng Wu, Zhaoning Zhu, Corey Strickland, Johannes Voigt, Xia Chen, Matthew E. Kennedy, Reshma Kuvelkar, Lynn A. Hyde, Kathleen Cox, Leonard Favreau, Michael F. Czarniecki, William J. Greenlee, Brian A. McKittrick, Eric M. Parker, Andrew W. Stamford, Structure based design of iminohydantoin BACE1 inhibitors: Identification of an orally available, centrally active BACE1 inhibitor, Bioorg. Med. Chem. Letts, 22, 2044 (2012).
  198. Andrew W. Stamford, Jack D. Scott, Sarah W. Li, Suresh Babu, Dawit Tadesse, Rachael Hunter, Yusheng Wu, Jeffrey Misiaszek, Jared N. Cumming, Eric J. Gilbert, Chunli Huang, Brian A. McKittrick, Liwu Hong, Tao Guo, Zhaoning Zhu†, Corey Strickland, Peter Orth, Johannes H. Voigt, Matthew E. Kennedy, Xia Chen, Reshma Kuvelkar, Robert Hodgson, Lynn A. Hyde, Kathleen Cox, Leonard Favreau, Eric M. Parker, William J. Greenlee, Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor that Affords Robust CNS Ab Reduction, ACS Medicinal Chemistry Letters, 3, 897 (2012).
  199. Mihirbaran Mandal, Zhaoning Zhu, Jared Cumming, Xiaoxiang Liu, Robert Mazzola, John Caldwell, Prescott Leach, Michael Grzelak, Lynn Hyde, Qi Zhang, Giuseppe Terracina, Lili Zhang, Xia Chen, Reshma Kuvelkar, Matthew Kennedy, Leonard Favreau, Kathleen Cox, Corey Strickland, Peter Orth, Johannes Voigt, Hongwu Wang, Irina Kazakevich, Brian McKittrick, William Greenlee, Eric Parker, and Andrew Stamford, Design and validation of bicyclic iminopyrimidinones as beta amyloid cleaving enzyme-1 (BACE1) inhibitors – Conformational constraint to favor a bioactive conformation, Journal of Medicinal Chemistry, 55, 9331 (2012). 
  200. Xianhai Huang, Wei Zhou, Xiaoxiang Liu, Hongmei Li, George Sun, Mihirbaran Mandal, Monica Vicarel, Xiaohong Zhu, Chad Bennett, Troy McCraken, Dmitri Pissarnitski, Zhiqiang Zhao, David Cole, Gioconda Gallo, Zhaoning Zhu, Anandan Palani, Robert Aslanian, John Clader, Michael F. Czarniecki, William Greenlee, Duane Burnett, Mary Cohen-Williams, Lynn Hyde, Lixin Song, Lili Zhang, Inhou Chu, and Alexei Buevich, The Synthesis and SAR Studies of Fused Oxadiazines as Gamma Secretase Modulators For Treatment of Alzheimer’s Disease, ACS Med. Chem. Letts., 3, 931 (2012).
  201. Stephanie Brumfield, Peter Korakas, Lisa S. Silverman, Deen Tulshian, Julius J. Matasi, Li Qiang, Chad E. Bennett, Duane A. Burnett, William J. Greenlee, Chad E. Knutson, Wen-Lian Wu, T.K. Sasikumar, Martin Domalski, Rosalia Bertorelli, Mariagrazia Grilli, Gianluca Lozza, Angelo Reggiani, Cheng Li, Synthesis and SAR development of novel mGluR1 antagonists for the treatment of chronic pain, Bioorg. Med. Chem. Letts, 22, 7223 (2012).
  202. Wen-Lian Wu, Martin Domalski, Duane A. Burnett, Hubert Josien, Thomas Bara, Murali Rajagopalan, Ruo Xu, John Clader, William J. Greenlee, Andrew Brunskill, Lynn A. Hyde, Robert A. Del Vecchio, Mary E. Cohen-Williams, Lixin Song, Julie Lee, Giuseppe Terracina, Qi Zhang, Amin Nomeir, Eric M. Parker, and Lili Zhang, Discovery of SCH 900229, a Potent Presenilin 1 Selective γ-Secretase Inhibitor for the Treatment of Alzheimer’s Disease, ACS Medicinal Chemistry Letters, 3, 892 (2012).
  203. Hongmei Li, Jun Qin, Pawan Dhondi, Wei Zhou, Monica Vicarel, Thomas Bara, David Cole, Hubert Josien, Dmitri Pissarnitski, Zhaoning Zhu, Anandan Palani, Robert Aslanian, John Clader, Michael Czarniecki, William Greenlee, Mary Cohen-Williams, Lynn Hyde, Lixin Song, Lili Zhang, Inhou Chu, Xianhai Huang, The discovery of fused oxadiazepines as gamma secretase modulators for treatment of Alzheimer’s disease, Bioorg. Med. Chem. Letts, 23, 466 (2013).
  204. Wen-Lian, Theodros Asberom, Thomas Bara, Chad Bennett, Duane A. Burnett, John Clader, Martin Domalski, William J. Greenlee,  Hubert Josien,  Mark McBriar, Murali Rajagopalan, Monica Vicarel, Ruo Xu, Lynn A. Hyde, Robert A. Del Vecchio, Mary E. Cohen-Williams, Lixin Song,  Julie Lee, Giuseppe Terracina, Qi Zhang, Amin Nomeir, Eric M. Parker, Lili Zhang, Structure activity relationship studies of tricyclic bispyran sulfone γ-secretase inhibitors, Bioorg. Med. Chem. Letts, 23, 844 (2013).
  205. Wen-Lian Wu, Thavalakulamgara K. Sasikumar, Martin S. Domalski, Li Qiang, Duane A. Burnett, John Clader, William J. Greenlee, Tze-Ming Chan, Julie Lee, Lili Zhang, A-ring modification of SCH 900229 and related chromene sulfone γ-secretase inhibitors, Bioorg. Med. Chem. Letts, 23, 850 (2013).
  206. Wen-Lian Wu, Thavalakulamgara K. Sasikumar, Martin S. Domalski, Li Qiang, Duane A. Burnett, John Clader, William J. Greenlee, Tze-Ming Chan, Julie Lee, Lili Zhang, A-ring modification of SCH 900229 and related chromene sulfone γ-secretase inhibitors, Bioorg. Med. Chem. Letts, 23, 850 (2013).
  207. Himbacine-Derived Thrombin Receptor Antagonists: C7-Aminomethyl and C9a-Hydroxy Analogs of Vorapaxar, Mariappan Vasu Chelliah, Samuel Chackalamannil, Yan Xia, William J. Greenlee, Ho-Sam Ahn, Stan Kurowski, George Boykow, Yunsheng Hsieh, Madhu Chintala, ACS Med. Chem. Letts., 5, 183 (2014).
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  217. Design And Synthesis of Water Soluble Gamma-Aminosulfone Analogues of SCH 900229 as Gamma-Secretase Inhibitors, Wen-Lian Wu, PhD; Duane A Burnett; John Clader; William J Greenlee; Qin Jiang; Lynn A Hyde; Robert A Del Vecchio; Mary E Cohen-Williams; Lixin Song; Julee Lee; Giuseppe  Terracina; Qi Zhang; Amin Nomeir; Eric M Parker; Lili Zhang, Bioorg. Med. Chem. Letts., 26, 5836–5841 (2016).
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